Superoxide flashes, reactive oxygen species, and the mitochondrial permeability transition pore: Potential implications for hematopoietic stem cell function

Charlie Mantel, Steven V. Messina-Graham, Hal E. Broxmeyer

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Purpose of Review: Reactive oxygen species (ROS) have an important function in blood cell homeostasis and hematopoietic diseases. Recent discoveries concerning how ROS are generated and regulated in mitochondria via the mitochondrial permeability transition pore (mPTP) and the new phenomenon, superoxide flashes, and ROS-induced ROS release, have not been investigated in hematopoietic stem and progenitor cells, but likely have important implications for their regulation and survival. Here we relate our opinions about these potential implications. Recent Findings: The mPTP has been recently implicated in ROS generation via binding of Stat3 transcription factor to a central component of the pore. SUMMARY: The implications of this new information for hematopoiesis regulation and transplantation methodologies could prove to be important, especially as they relate to myeloid neoplasm oncogenesis and potentially new therapeutic targets. New details about ROS production suggest that techniques for bone marrow and umbilical cord blood harvest may benefit from means to downmodulate ROS.

Original languageEnglish (US)
Pages (from-to)208-213
Number of pages6
JournalCurrent opinion in hematology
Volume18
Issue number4
DOIs
StatePublished - Jul 1 2011

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Keywords

  • hematopoietic stem cell
  • hypoxia
  • mitochondrial permeability transition pore
  • reactive oxygen species
  • transplantation

ASJC Scopus subject areas

  • Hematology

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