Supersensitivity to light

Possible trait marker for manic-depressive illness

A. J. Lewy, John Nurnberger, T. A. Wehr, D. Pack, L. E. Becker, R. L. Powell, D. A. Newsome

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

Exposure to light during the night reduces plasma melatonin levels. A previous study showed that, in response to light, nighttime plasma melatonin levels fell twice as much in a group of acutely ill manic-depressive patients as in a group of normal subjects. The present study compares 11 euthymic manic-depressive patients not taking medications with 24 age- and sex-matched normal subjects. Melatonin levels in these patients also fell twice as much as the levels of the normal subjects, suggesting that supersensitivity to light may be a trait marker for bipolar affective disorder.

Original languageEnglish (US)
Pages (from-to)725-727
Number of pages3
JournalAmerican Journal of Psychiatry
Volume142
Issue number6
StatePublished - 1985
Externally publishedYes

Fingerprint

Melatonin
Light
Mood Disorders
Bipolar Disorder
Major Affective Disorder 2

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Lewy, A. J., Nurnberger, J., Wehr, T. A., Pack, D., Becker, L. E., Powell, R. L., & Newsome, D. A. (1985). Supersensitivity to light: Possible trait marker for manic-depressive illness. American Journal of Psychiatry, 142(6), 725-727.

Supersensitivity to light : Possible trait marker for manic-depressive illness. / Lewy, A. J.; Nurnberger, John; Wehr, T. A.; Pack, D.; Becker, L. E.; Powell, R. L.; Newsome, D. A.

In: American Journal of Psychiatry, Vol. 142, No. 6, 1985, p. 725-727.

Research output: Contribution to journalArticle

Lewy, AJ, Nurnberger, J, Wehr, TA, Pack, D, Becker, LE, Powell, RL & Newsome, DA 1985, 'Supersensitivity to light: Possible trait marker for manic-depressive illness', American Journal of Psychiatry, vol. 142, no. 6, pp. 725-727.
Lewy, A. J. ; Nurnberger, John ; Wehr, T. A. ; Pack, D. ; Becker, L. E. ; Powell, R. L. ; Newsome, D. A. / Supersensitivity to light : Possible trait marker for manic-depressive illness. In: American Journal of Psychiatry. 1985 ; Vol. 142, No. 6. pp. 725-727.
@article{23409a5547de49cd9910dec4dcdba7a2,
title = "Supersensitivity to light: Possible trait marker for manic-depressive illness",
abstract = "Exposure to light during the night reduces plasma melatonin levels. A previous study showed that, in response to light, nighttime plasma melatonin levels fell twice as much in a group of acutely ill manic-depressive patients as in a group of normal subjects. The present study compares 11 euthymic manic-depressive patients not taking medications with 24 age- and sex-matched normal subjects. Melatonin levels in these patients also fell twice as much as the levels of the normal subjects, suggesting that supersensitivity to light may be a trait marker for bipolar affective disorder.",
author = "Lewy, {A. J.} and John Nurnberger and Wehr, {T. A.} and D. Pack and Becker, {L. E.} and Powell, {R. L.} and Newsome, {D. A.}",
year = "1985",
language = "English (US)",
volume = "142",
pages = "725--727",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "6",

}

TY - JOUR

T1 - Supersensitivity to light

T2 - Possible trait marker for manic-depressive illness

AU - Lewy, A. J.

AU - Nurnberger, John

AU - Wehr, T. A.

AU - Pack, D.

AU - Becker, L. E.

AU - Powell, R. L.

AU - Newsome, D. A.

PY - 1985

Y1 - 1985

N2 - Exposure to light during the night reduces plasma melatonin levels. A previous study showed that, in response to light, nighttime plasma melatonin levels fell twice as much in a group of acutely ill manic-depressive patients as in a group of normal subjects. The present study compares 11 euthymic manic-depressive patients not taking medications with 24 age- and sex-matched normal subjects. Melatonin levels in these patients also fell twice as much as the levels of the normal subjects, suggesting that supersensitivity to light may be a trait marker for bipolar affective disorder.

AB - Exposure to light during the night reduces plasma melatonin levels. A previous study showed that, in response to light, nighttime plasma melatonin levels fell twice as much in a group of acutely ill manic-depressive patients as in a group of normal subjects. The present study compares 11 euthymic manic-depressive patients not taking medications with 24 age- and sex-matched normal subjects. Melatonin levels in these patients also fell twice as much as the levels of the normal subjects, suggesting that supersensitivity to light may be a trait marker for bipolar affective disorder.

UR - http://www.scopus.com/inward/record.url?scp=0021849992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021849992&partnerID=8YFLogxK

M3 - Article

VL - 142

SP - 725

EP - 727

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 6

ER -