Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis

M. D. Benson, M. A. Aldo-Benson, T. Shirahama, Y. Borel, A. S. Cohen

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Serum from CBA/J mice made amyloidotic by chronic casein injections suppresses in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed by absorption of the sera with antiserum to protein AA, the major constituent of casein induced (secondary) amyloid fibrils. The antiserum to the amyloid fibril protein AA (mol wt 8,400 daltons) detects an immunologically cross reacting serum alpha globulin (SAA) (mol wt approx. 100,000). It is postulated that the serum factor (SAA) is a regulator of antibody response and may be present in elevated amounts as the result of chronic antigenic stimulation.

Original languageEnglish (US)
Pages (from-to)236-241
Number of pages6
JournalJournal of Experimental Medicine
Volume142
Issue number1
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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