Suppression of in vitro maintenance of non-promyelocytic myeloid leukemia clonogenic cells by all-trans retinoic acid: Modulating effects of dihydroxylated vitamin D3, α interferon and 'stem cell factor'

Dario Ferrero, Nadia Carlesso, Paola Bresso, Viviana Roux, Patrizia Pregno, Eugenio Gallo, Alessandro Pileri

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

In a liquid culture system, all-trans retinoic acid (ATRA), alone and in combination with dihydroxylated vitamin D3 (D3) or α interferon (αIFN) at concentrations achievable in vivo, could significantly suppress the maintenance of non-promyelocytic myeloid leukemia clonogenic cells (CFU-L) in 9/20, 9/18 and 7/11 cases, respectively. That suppression was counteracted only slightly by the addition of 'stem cell factor', a cytokine which promotes CFU-L expansion in vitro. Differentiated cells slightly increased in 5/17 cases only, suggesting the prevalence of anti-proliferative rather than differentiating mechanisms. The present results extend our previous ones and suggest the possible therapeutical value of ATRA+D3 or αIFN, even in cases of non-promyelocytic myeloid leukemia.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalLeukemia Research
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Clonogenic cells
  • Dihydroxylated vitamin D3
  • Retinoic acid
  • Stem cell factor
  • α interferon

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Suppression of in vitro maintenance of non-promyelocytic myeloid leukemia clonogenic cells by all-trans retinoic acid: Modulating effects of dihydroxylated vitamin D3, α interferon and 'stem cell factor''. Together they form a unique fingerprint.

  • Cite this