Suppression of mitogen-induced lymphocyte transformation in cigarette smokers

B. H. Petersen, L. F. Steimel, J. T. Callaghan

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Mitogen- and antigen-induced lymphocyte transformation was determined in peripheral blood lymphocytes from tobacco smokers and nonsmokers. Each group was evaluated by race, sex, and age subgroups. Male smokers as a group had depressed responses to phytohemagglutinin (PHA), concanavalin A, and pokeweed mitogen. The effect was most pronounced in all subjects on PHA stimulation. There was no apparent relationship to age or race. Antigenic stimulation of lymphocytes with mumps skin test antigen was not affected in any of the groups studied.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalClinical Immunology and Immunopathology
Volume27
Issue number1
DOIs
StatePublished - Apr 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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