A number of biologically active and biochemically well-characterized cytokines have been shown to have either direct or indirect suppressive activities on the proliferation/differentiation of myeloid stem/progenitor cells. This article is a brief review of the actions of some of these molecules. These molecules include H-subunit ferritin, macrophage inflammatory protein-lα, the interferons-α, -β, and -γ, the tumor necrosis factors-α and -β (lymphotoxin), prostaglandins, E1 and E2, inhibin, transforming growth factor-β, and lactoferrin. I will also review the actions of other suppressor molecules, including a newly identified 8-kd molecule that has not yet been sequenced and a synthetic pentapeptide. Current information is given on the in vitro actions of these molecules together with their activity in vivo in animal models. Possibilities for their clinical use are discussed.
- Suppressor molecules
- Synthetic pentapeptide
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health