Suppressor cytokines and regulation of myelopoiesis: Biology and possible clinical uses

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Abstract

A number of biologically active and biochemically well-characterized cytokines have been shown to have either direct or indirect suppressive activities on the proliferation/differentiation of myeloid stem/progenitor cells. This article is a brief review of the actions of some of these molecules. These molecules include H-subunit ferritin, macrophage inflammatory protein-lα, the interferons-α, -β, and -γ, the tumor necrosis factors-α and -β (lymphotoxin), prostaglandins, E1 and E2, inhibin, transforming growth factor-β, and lactoferrin. I will also review the actions of other suppressor molecules, including a newly identified 8-kd molecule that has not yet been sequenced and a synthetic pentapeptide. Current information is given on the in vitro actions of these molecules together with their activity in vivo in animal models. Possibilities for their clinical use are discussed.

Original languageEnglish
Pages (from-to)22-30
Number of pages9
JournalJournal of Pediatric Hematology/Oncology
Volume14
Issue number1
StatePublished - 1992

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Myelopoiesis
Myeloid Progenitor Cells
Tumor Necrosis Factors
Apoferritins
Cytokines
Macrophage Inflammatory Proteins
Lymphotoxin-alpha
Inhibins
Lactoferrin
Alprostadil
Transforming Growth Factors
Dinoprostone
Interferons
Animal Models
In Vitro Techniques

Keywords

  • Cytokines
  • Suppressor molecules
  • Synthetic pentapeptide

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

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