Supraesophageal manifestations of gastroesophageal reflux disease

G. Al-Sabbagh, J. M. Wo

Research output: Contribution to journalReview article

26 Scopus citations


An increasing amount of evidence indicates that gastroesophageal reflux disease (GERD) is a contributing factor to hoarseness, throat clearing, throat discomfort, chronic cough, and shortness of breath. The association between GERD and these supraesophageal symptoms may be elusive. Heartburn and regurgitation are absent in more than 50% of patients. Acid reflux should be considered if signs of GERD are present, symptoms are unexplained, or symptoms are refractory to therapy. The diagnosis of GERD may be unclear, despite a careful history and initial evaluation. A high index of suspicion is required to make the diagnosis. An empiric trial of antireflux therapy is appropriate when GERD is suspected. Multiprobe ambulatory pH monitoring is currently the diagnostic test of choice, but the level of sensitivity and specificity for supraesophageal manifestations of GERD is uncertain. Response to antireflux therapy is less predictable than typical GERD. More intensive acid suppression and longer treatment duration are usually required.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalSeminars in Gastrointestinal Disease
Issue number3
StatePublished - Jul 29 1999
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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