Supratentorial malignant gliomas in childhood

A review of fifty cases

Edward Dropcho, J. H. Wisoff, R. W. Walker, J. C. Allen

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

From 1977 to 1986, 50 children aged 15 months to 18 years were treated for supratentorial malignant gliomas at the Memorial Sloan-Kettering Cancer Center and the New York University Medical Center. Thirteen patients had glioblastoma multiforme, 29 had anaplastic astrocytomas, and 8 had malignant gliomas. In 10 patients the tumor evolved from a low-grade lesion. Seven patients, including 2 patients with neurofibromatosis, developed multiple primary malignant neoplasms. The median time to tumor progression after surgery was 31 weeks, with local recurrence representing the mode of treatment failure in nearly all patients. Notable clinical features included symptomatic leptomeningeal metastasis (13 patients) and intratumoral hemorrhage (9 patients). The estimated median survival time for all 50 patients was 98 weeks, with a 3-year-survival rate of 32%. A trend toward longer survival was seen in patients 12 years of age or younger at diagnosis. There was no apparent correlation between survival and tumor histology or tumor location. Recommendations for management are presented.

Original languageEnglish (US)
Pages (from-to)355-364
Number of pages10
JournalAnnals of Neurology
Volume22
Issue number3
StatePublished - 1987
Externally publishedYes

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Glioma
Neoplasms
Survival
Multiple Primary Neoplasms
Neurofibromatoses
Astrocytoma
Glioblastoma
Treatment Failure
Histology
Survival Rate
Hemorrhage
Neoplasm Metastasis
Recurrence

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dropcho, E., Wisoff, J. H., Walker, R. W., & Allen, J. C. (1987). Supratentorial malignant gliomas in childhood: A review of fifty cases. Annals of Neurology, 22(3), 355-364.

Supratentorial malignant gliomas in childhood : A review of fifty cases. / Dropcho, Edward; Wisoff, J. H.; Walker, R. W.; Allen, J. C.

In: Annals of Neurology, Vol. 22, No. 3, 1987, p. 355-364.

Research output: Contribution to journalArticle

Dropcho, E, Wisoff, JH, Walker, RW & Allen, JC 1987, 'Supratentorial malignant gliomas in childhood: A review of fifty cases', Annals of Neurology, vol. 22, no. 3, pp. 355-364.
Dropcho, Edward ; Wisoff, J. H. ; Walker, R. W. ; Allen, J. C. / Supratentorial malignant gliomas in childhood : A review of fifty cases. In: Annals of Neurology. 1987 ; Vol. 22, No. 3. pp. 355-364.
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