Surface-based morphometric analysis of hippocampal subfields in mild cognitive impairment and Alzheimer's disease

Shan Cong, Maher Rizkalla, Paul Salama, John West, Shannon Risacher, Andrew Saykin, Li Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

The hippocampus is widely studied with neuroimaging techniques given its importance in learning and memory and its potential as a biomarker for Alzheimer's disease (AD). Its complex folding anatomy often presents analytical challenges. In particular, the critical subfield information is typically not addressed by the existing hippocampal shape studies. To bridge this gap, we present a computational framework for surface-based morphometric analysis of hippocampal subfields. The major strengths of this framework are as follows: (a) it performs detailed hippocampal shape analysis, (b) it embraces, rather than ignores, the important hippocampal subfield information, and (c) it analyzes regular magnetic resonance imaging scans and is applicable to large scale studies. We demonstrate its effectiveness by applying it to the identification of regional hippocampal subfield atrophy patterns associated with mild cognitive impairment and AD.

Original languageEnglish (US)
Title of host publicationIEEE 58th International Midwest Symposium on Circuits and Systems
Subtitle of host publicationClimbing to New Heights, MWSCAS 2015 - Conference Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781467365574
DOIs
StatePublished - Sep 28 2015
Event58th IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2015 - Fort Collins, United States
Duration: Aug 2 2015Aug 5 2015

Publication series

NameMidwest Symposium on Circuits and Systems
Volume2015-September
ISSN (Print)1548-3746

Other

Other58th IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2015
CountryUnited States
CityFort Collins
Period8/2/158/5/15

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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    Cong, S., Rizkalla, M., Salama, P., West, J., Risacher, S., Saykin, A., & Shen, L. (2015). Surface-based morphometric analysis of hippocampal subfields in mild cognitive impairment and Alzheimer's disease. In IEEE 58th International Midwest Symposium on Circuits and Systems: Climbing to New Heights, MWSCAS 2015 - Conference Proceedings [7282173] (Midwest Symposium on Circuits and Systems; Vol. 2015-September). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MWSCAS.2015.7282173