Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly

Liana G. Apostolova, Paul M. Thompson, Steve A. Rogers, Ivo D. Dinov, Charleen Zoumalan, Calen A. Steiner, Erin Siu, Amity E. Green, Gary W. Small, Arthur W. Toga, Jeffrey L. Cummings, Michael E. Phelps, Daniel H. Silverman

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. Procedures: Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4±0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET scan (interval 21.7±3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique. Results: Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10-15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5-5% similarly distributed decline. ApoE4-positive individuals underwent 5-15% metabolic decline in the posterior association cortices. Conclusions: Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalMolecular Imaging and Biology
Volume12
Issue number2
DOIs
StatePublished - Apr 1 2010

Fingerprint

Positron-Emission Tomography
Parietal Lobe
Apolipoprotein E4
Occipital Lobe
Temporal Lobe
Glucose
Gyrus Cinguli
Frontal Lobe
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging

Keywords

  • Alzheimer's disease (AD)
  • Cognitive decline
  • Mild cognitive impairment (MCI)
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly. / Apostolova, Liana G.; Thompson, Paul M.; Rogers, Steve A.; Dinov, Ivo D.; Zoumalan, Charleen; Steiner, Calen A.; Siu, Erin; Green, Amity E.; Small, Gary W.; Toga, Arthur W.; Cummings, Jeffrey L.; Phelps, Michael E.; Silverman, Daniel H.

In: Molecular Imaging and Biology, Vol. 12, No. 2, 01.04.2010, p. 218-224.

Research output: Contribution to journalArticle

Apostolova, LG, Thompson, PM, Rogers, SA, Dinov, ID, Zoumalan, C, Steiner, CA, Siu, E, Green, AE, Small, GW, Toga, AW, Cummings, JL, Phelps, ME & Silverman, DH 2010, 'Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly', Molecular Imaging and Biology, vol. 12, no. 2, pp. 218-224. https://doi.org/10.1007/s11307-009-0247-7
Apostolova, Liana G. ; Thompson, Paul M. ; Rogers, Steve A. ; Dinov, Ivo D. ; Zoumalan, Charleen ; Steiner, Calen A. ; Siu, Erin ; Green, Amity E. ; Small, Gary W. ; Toga, Arthur W. ; Cummings, Jeffrey L. ; Phelps, Michael E. ; Silverman, Daniel H. / Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly. In: Molecular Imaging and Biology. 2010 ; Vol. 12, No. 2. pp. 218-224.
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AU - Siu, Erin

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