Surface membrane polarity of proximal tubular cells: Alterations as a basis for malfunction

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The surface membrane of proximal tubular cells is organized into distinct apical and basolateral membrane domains. The establishment and maintenance of these biochemically, structurally and physiologically distinct domains involves a multi-stage process involving cell-cell, cell-ECM interactions, and polarized targeting mechanisms. Ischemia, via cellular ATP depletion, results in a series of structural, biochemical and functional alterations that lead to loss of proximal tubular cell surface membrane polarity. Of central importance is the rapidly-occurring, duration-dependent disruption and dissociation of the actin cytoskeleton and associated surface membrane structures. This results in numerous cellular alterations including loss of cell-cell contact, cell extracellular matrix adhesion and surface membrane polarity. Redistribution of surface membrane proteins and lipids into the alternate domain results in the cells inability to function properly. Repair of these disorders involves re-establishment of the actin cytoskeleton and apical and basolateral surface membrane domains. Recent information indicates growth factors may play a role in hastening this repair process.

Original languageEnglish
Pages (from-to)1592-1597
Number of pages6
JournalKidney International
Volume49
Issue number6
StatePublished - 1996

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Membranes
Actin Cytoskeleton
Membrane Proteins
Cell-Matrix Junctions
Membrane Lipids
Cell Communication
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Ischemia
Adenosine Triphosphate
Maintenance
Cell Membrane

ASJC Scopus subject areas

  • Nephrology

Cite this

Surface membrane polarity of proximal tubular cells : Alterations as a basis for malfunction. / Molitoris, Bruce; Wagner, Mark.

In: Kidney International, Vol. 49, No. 6, 1996, p. 1592-1597.

Research output: Contribution to journalArticle

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