Surgery to treat focal frontal lobe epilepsy in adults

Johannes Schramm, Thomas Kral, Martin Kurthen, Ingmar Blümcke, Nicholas Barbaro, Robert G. Grossman, Allen R. Wyler, Kim J. Burchiel

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

OBJECTIVE: To report clinical, neuropathological, and outcome data for a series of adult patients with focal frontal lobe epilepsy (fFLE) who underwent nonlobar resection restricted to the frontal lobe. METHODS: Sixty-eight adult cases (24 female and 44 male patients) were included in the study, on the basis of prospectively collected data that were retrospectively evaluated. There were 68 lesionectomies, 17 of which were combined with multiple subpial transection, with a mean follow-up period of 28.4 ± 23.3 months. Cases involving additional extrafrontal surgery were excluded. RESULTS: Thirty-seven patients underwent invasive preoperative evaluations, and 31 underwent noninvasive evaluations. Intraoperative electrocorticography was used in 32% of cases. There were 24 tumors, 18 dysgenetic lesions, 14 gliotic lesions, and 10 vascular malformations. Fifteen tumors were of glial origin, one was a dysembryoplastic neuroepithelial tumor, and eight were gangliogliomas. The most common dysgenetic lesions were hamartomas (15 cases). Outcomes (classified into four Engel groups) were as follows: Class I, 54%; Class II, 19%; Class III, 15%; Class IV, 12%. Seizure-free rates were comparable for tumor and dysgenesis cases and were not as good for vascular malformation and gliosis cases. Outcome differences were not significant with respect to aura presence, side of surgery, age at the time of surgery, and age at seizure onset. There were 3 cases of surgical complications, 10 cases of transient neurological disturbances, and 1 case involving a permanent neurological deficit. No deaths occurred. CONCLUSION: Outcomes with fFLE surgery have improved, compared with historical series. fFLE resections restricted to the frontal lobe did not yield seizure-free rates as good as those for comparable nonfocal frontal lobe epilepsy series. All fFLE cases demonstrated histological lesions. fFLE surgery was associated with a higher risk of transient neurological deficits, most likely because of the necessity for multiple subpial transection. The outcomes and higher rates of invasive evaluations and intraoperative electrocorticography indicate the special complexities of frontal lobe epilepsy. The permanent neurological disability rate was low in this series, and there were no deaths.

Original languageEnglish (US)
Pages (from-to)644-655
Number of pages12
JournalNeurosurgery
Volume51
Issue number3
DOIs
StatePublished - Sep 1 2002
Externally publishedYes

Fingerprint

Frontal Lobe Epilepsy
Partial Epilepsy
Vascular Malformations
Seizures
Frontal Lobe
Ganglioglioma
Neuroepithelial Neoplasms
Neoplasms
Gliosis
Hamartoma
Age of Onset
Neuroglia
Epilepsy

Keywords

  • Epilepsy surgery
  • Frontal lobe
  • Frontal lobe epilepsy
  • Lesionectomy
  • Multiple subpial transection

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Schramm, J., Kral, T., Kurthen, M., Blümcke, I., Barbaro, N., Grossman, R. G., ... Burchiel, K. J. (2002). Surgery to treat focal frontal lobe epilepsy in adults. Neurosurgery, 51(3), 644-655. https://doi.org/10.1097/00006123-200209000-00008

Surgery to treat focal frontal lobe epilepsy in adults. / Schramm, Johannes; Kral, Thomas; Kurthen, Martin; Blümcke, Ingmar; Barbaro, Nicholas; Grossman, Robert G.; Wyler, Allen R.; Burchiel, Kim J.

In: Neurosurgery, Vol. 51, No. 3, 01.09.2002, p. 644-655.

Research output: Contribution to journalArticle

Schramm, J, Kral, T, Kurthen, M, Blümcke, I, Barbaro, N, Grossman, RG, Wyler, AR & Burchiel, KJ 2002, 'Surgery to treat focal frontal lobe epilepsy in adults', Neurosurgery, vol. 51, no. 3, pp. 644-655. https://doi.org/10.1097/00006123-200209000-00008
Schramm J, Kral T, Kurthen M, Blümcke I, Barbaro N, Grossman RG et al. Surgery to treat focal frontal lobe epilepsy in adults. Neurosurgery. 2002 Sep 1;51(3):644-655. https://doi.org/10.1097/00006123-200209000-00008
Schramm, Johannes ; Kral, Thomas ; Kurthen, Martin ; Blümcke, Ingmar ; Barbaro, Nicholas ; Grossman, Robert G. ; Wyler, Allen R. ; Burchiel, Kim J. / Surgery to treat focal frontal lobe epilepsy in adults. In: Neurosurgery. 2002 ; Vol. 51, No. 3. pp. 644-655.
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N2 - OBJECTIVE: To report clinical, neuropathological, and outcome data for a series of adult patients with focal frontal lobe epilepsy (fFLE) who underwent nonlobar resection restricted to the frontal lobe. METHODS: Sixty-eight adult cases (24 female and 44 male patients) were included in the study, on the basis of prospectively collected data that were retrospectively evaluated. There were 68 lesionectomies, 17 of which were combined with multiple subpial transection, with a mean follow-up period of 28.4 ± 23.3 months. Cases involving additional extrafrontal surgery were excluded. RESULTS: Thirty-seven patients underwent invasive preoperative evaluations, and 31 underwent noninvasive evaluations. Intraoperative electrocorticography was used in 32% of cases. There were 24 tumors, 18 dysgenetic lesions, 14 gliotic lesions, and 10 vascular malformations. Fifteen tumors were of glial origin, one was a dysembryoplastic neuroepithelial tumor, and eight were gangliogliomas. The most common dysgenetic lesions were hamartomas (15 cases). Outcomes (classified into four Engel groups) were as follows: Class I, 54%; Class II, 19%; Class III, 15%; Class IV, 12%. Seizure-free rates were comparable for tumor and dysgenesis cases and were not as good for vascular malformation and gliosis cases. Outcome differences were not significant with respect to aura presence, side of surgery, age at the time of surgery, and age at seizure onset. There were 3 cases of surgical complications, 10 cases of transient neurological disturbances, and 1 case involving a permanent neurological deficit. No deaths occurred. CONCLUSION: Outcomes with fFLE surgery have improved, compared with historical series. fFLE resections restricted to the frontal lobe did not yield seizure-free rates as good as those for comparable nonfocal frontal lobe epilepsy series. All fFLE cases demonstrated histological lesions. fFLE surgery was associated with a higher risk of transient neurological deficits, most likely because of the necessity for multiple subpial transection. The outcomes and higher rates of invasive evaluations and intraoperative electrocorticography indicate the special complexities of frontal lobe epilepsy. The permanent neurological disability rate was low in this series, and there were no deaths.

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