Surgical decompression in acute spinal cord injury: A review of clinical evidence, animal model studies, and potential future directions of investigation

Yiping Li, Chandler L. Walker, Yi Ping Zhang, Christopher B. Shields, Xiao Ming Xu

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The goal for treatment in acute spinal cord injury (SCI) is to reduce the extent of secondary damage and facilitate neurologic regeneration and functional recovery. Although multiple studies have investigated potential new therapies for the treatment of acute SCI, outcomes and management protocols aimed at ameliorating neurologic injury in patients remain ineffective. More recent clinical and basic science research have shown surgical interventions to be a potentially valuable modality for treatment; however, the role and timing of surgical decompression, in addition to the optimal surgical intervention, remain one of the most controversial topics pertaining to surgical treatment of acute SCI. As an increasing number of potential treatment modalities emerge, animal models are pivotal for investigating its clinical application and translation into human trials. This review critically appraises the available literature for both clinical and basic science studies to highlight the extent of investigation that has occurred, specific therapies considered, and potential areas for future research.

Original languageEnglish (US)
Pages (from-to)127-136
Number of pages10
JournalFrontiers in Biology
Volume9
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Surgical Decompression
decompression
Spinal Cord Injuries
spinal cord
Animal Models
animal models
nervous system
animal
therapeutics
Therapeutics
regeneration
Nervous System Trauma
damage
Direction compound
Nervous System
Regeneration
therapy
science
Research

Keywords

  • acute spinal cord injury
  • animal models
  • durotomy
  • surgical decompression

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology
  • Genetics
  • Ecology

Cite this

Surgical decompression in acute spinal cord injury : A review of clinical evidence, animal model studies, and potential future directions of investigation. / Li, Yiping; Walker, Chandler L.; Zhang, Yi Ping; Shields, Christopher B.; Xu, Xiao Ming.

In: Frontiers in Biology, Vol. 9, No. 2, 02.2014, p. 127-136.

Research output: Contribution to journalReview article

@article{363a7a41696c4845bb670ecad72d8a2d,
title = "Surgical decompression in acute spinal cord injury: A review of clinical evidence, animal model studies, and potential future directions of investigation",
abstract = "The goal for treatment in acute spinal cord injury (SCI) is to reduce the extent of secondary damage and facilitate neurologic regeneration and functional recovery. Although multiple studies have investigated potential new therapies for the treatment of acute SCI, outcomes and management protocols aimed at ameliorating neurologic injury in patients remain ineffective. More recent clinical and basic science research have shown surgical interventions to be a potentially valuable modality for treatment; however, the role and timing of surgical decompression, in addition to the optimal surgical intervention, remain one of the most controversial topics pertaining to surgical treatment of acute SCI. As an increasing number of potential treatment modalities emerge, animal models are pivotal for investigating its clinical application and translation into human trials. This review critically appraises the available literature for both clinical and basic science studies to highlight the extent of investigation that has occurred, specific therapies considered, and potential areas for future research.",
keywords = "acute spinal cord injury, animal models, durotomy, surgical decompression",
author = "Yiping Li and Walker, {Chandler L.} and Zhang, {Yi Ping} and Shields, {Christopher B.} and Xu, {Xiao Ming}",
year = "2014",
month = "2",
doi = "10.1007/s11515-014-1297-z",
language = "English (US)",
volume = "9",
pages = "127--136",
journal = "Frontiers in Biology",
issn = "1674-7984",
publisher = "Higher Education Press",
number = "2",

}

TY - JOUR

T1 - Surgical decompression in acute spinal cord injury

T2 - A review of clinical evidence, animal model studies, and potential future directions of investigation

AU - Li, Yiping

AU - Walker, Chandler L.

AU - Zhang, Yi Ping

AU - Shields, Christopher B.

AU - Xu, Xiao Ming

PY - 2014/2

Y1 - 2014/2

N2 - The goal for treatment in acute spinal cord injury (SCI) is to reduce the extent of secondary damage and facilitate neurologic regeneration and functional recovery. Although multiple studies have investigated potential new therapies for the treatment of acute SCI, outcomes and management protocols aimed at ameliorating neurologic injury in patients remain ineffective. More recent clinical and basic science research have shown surgical interventions to be a potentially valuable modality for treatment; however, the role and timing of surgical decompression, in addition to the optimal surgical intervention, remain one of the most controversial topics pertaining to surgical treatment of acute SCI. As an increasing number of potential treatment modalities emerge, animal models are pivotal for investigating its clinical application and translation into human trials. This review critically appraises the available literature for both clinical and basic science studies to highlight the extent of investigation that has occurred, specific therapies considered, and potential areas for future research.

AB - The goal for treatment in acute spinal cord injury (SCI) is to reduce the extent of secondary damage and facilitate neurologic regeneration and functional recovery. Although multiple studies have investigated potential new therapies for the treatment of acute SCI, outcomes and management protocols aimed at ameliorating neurologic injury in patients remain ineffective. More recent clinical and basic science research have shown surgical interventions to be a potentially valuable modality for treatment; however, the role and timing of surgical decompression, in addition to the optimal surgical intervention, remain one of the most controversial topics pertaining to surgical treatment of acute SCI. As an increasing number of potential treatment modalities emerge, animal models are pivotal for investigating its clinical application and translation into human trials. This review critically appraises the available literature for both clinical and basic science studies to highlight the extent of investigation that has occurred, specific therapies considered, and potential areas for future research.

KW - acute spinal cord injury

KW - animal models

KW - durotomy

KW - surgical decompression

UR - http://www.scopus.com/inward/record.url?scp=84897518421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897518421&partnerID=8YFLogxK

U2 - 10.1007/s11515-014-1297-z

DO - 10.1007/s11515-014-1297-z

M3 - Review article

AN - SCOPUS:84897518421

VL - 9

SP - 127

EP - 136

JO - Frontiers in Biology

JF - Frontiers in Biology

SN - 1674-7984

IS - 2

ER -