Surgical Transgastric Necrosectomy for Necrotizing Pancreatitis: A Single-stage Procedure for Walled-off Pancreatic Necrosis

Michael Driedger, Nicholas J. Zyromski, Brendan C. Visser, Andrea Jester, Francis R. Sutherland, Atilla Nakeeb, Elijah Dixon, Monica M. Dua, Michael G. House, David J. Worhunsky, Gitonga Munene, Chad G. Ball

Research output: Contribution to journalArticle

7 Scopus citations


Objective: The aim of this study was to evaluate the role of surgical transgastric necrosectomy (TGN) for walled-off pancreatic necrosis (WON) in selected patients. Background: WON is a common consequence of severe pancreatitis and typically occurs 3 to 5 weeks after the onset of acute pancreatitis. When symptomatic, it can require intervention. Methods: A retrospective review of patients with WON undergoing surgical management at 3 high-volume pancreatic institutions was performed. Surgical indications, intervention timing, technical methodology, and patient outcomes were evaluated. Patients undergoing intervention <30 days were excluded. Differences across centers were evaluated using a P value of <0.05 as significant. Results: One hundred seventy-eight total patients were analyzed (mean WON diameter = 14'cm, 64% male, mean age = 51 years) across 3 centers. The majority required inpatient admission with a median preoperative length of hospital stay of 29 days (25% required preoperative critical care support). Most (96%) patients underwent a TGN. The median duration of time between the onset of pancreatitis symptoms and operative intervention was 60 days. Thirty-nine percent of the necrosum was infected. Postoperative morbidity and mortality were 38% and 2%, respectively. The median postoperative length of hospital length of stay was 8 days, with the majority of patients discharged home. The median length of follow-up was 21 months, with 91% of patients having complete clinical resolution of symptoms at a median of 6 weeks. Readmission to hospital and/or a repeat intervention was also not infrequent (20%).Conclusion: Surgical TGN is an excellent 1-stage surgical option for symptomatic WON in a highly selected group of patients. Precise surgical technique and long-term outpatient follow-up are mandatory for optimal patient outcomes.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalAnnals of surgery
Issue number1
StatePublished - Jan 1 2020



  • outcomes
  • transgastric cystgastrostomy
  • walled-off pancreatic necrosis
  • WOPN

ASJC Scopus subject areas

  • Surgery

Cite this

Driedger, M., Zyromski, N. J., Visser, B. C., Jester, A., Sutherland, F. R., Nakeeb, A., Dixon, E., Dua, M. M., House, M. G., Worhunsky, D. J., Munene, G., & Ball, C. G. (2020). Surgical Transgastric Necrosectomy for Necrotizing Pancreatitis: A Single-stage Procedure for Walled-off Pancreatic Necrosis. Annals of surgery, 271(1), 163-168.