Surgical treatment of total colonic aganglionosis

Efficacy of aganglionic patch enteroplasty in the rat

Seiichi Goto, Michael Gunter, L. R. Scherer, Ted Bloch, Jay L. Grosfeld

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This study evaluates ileoendorectal pull-through (IEP) with and without an aganglionic colon patch in an experimental rat model for the surgical treatment of total colonic aganglionosis (TCA). Animals were randomly assigned to Group 1 (no patch, No.=6), Group 2 (right colon patch, No.=8), Group 3 (transverse colon patch, No.=7), Group 4 (left colon patch; No.=6), sham operation (SH, No.=6). and unoperated controls (UC, No.=10). Change in percent body weight at 4 weeks after operation was -30.9±3.68% in Group 1, +5.1±1.67% in Group 2, -3.4±3.96% in Group 3, -1.8±4.17% in Group 4, and +12.7±1.54% in SH (Group 1 v other groups: P<.001). Restoration of initial body weight occurred in 100% in Group 2 and SH (8/8 and 6/6, respectively), 50% in Group 4 (3/6), 42.9% in Group 3 (3/7), and 0% in Group 1 (0/6). Transit time (stomach to anus) was significantly shorter in Group 1. All rats in patched groups had a prolonged transit time compared with Group 1. Manometric studies in IEP rats showed favorable anal canal pressures, which were slightly lower than SH and UC. Water and Na+ absorption were significantly greater in patched groups. Rats with a right colon patch (Group 2) showed slightly greater absorption at 4 weeks. These data suggest that an aganglionic colon patch may be an important adjunct in the surgical treatment of TCA.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalJournal of Pediatric Surgery
Volume21
Issue number7
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Hirschsprung Disease
Colon
Anal Canal
Body Weight
Transverse Colon
Stomach
Theoretical Models
Pressure
Water

Keywords

  • Hirschsprung's disease
  • ileoendorectal pull-through
  • Total colonic aganglionosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Surgical treatment of total colonic aganglionosis : Efficacy of aganglionic patch enteroplasty in the rat. / Goto, Seiichi; Gunter, Michael; Scherer, L. R.; Bloch, Ted; Grosfeld, Jay L.

In: Journal of Pediatric Surgery, Vol. 21, No. 7, 1986, p. 601-607.

Research output: Contribution to journalArticle

Goto, Seiichi ; Gunter, Michael ; Scherer, L. R. ; Bloch, Ted ; Grosfeld, Jay L. / Surgical treatment of total colonic aganglionosis : Efficacy of aganglionic patch enteroplasty in the rat. In: Journal of Pediatric Surgery. 1986 ; Vol. 21, No. 7. pp. 601-607.
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abstract = "This study evaluates ileoendorectal pull-through (IEP) with and without an aganglionic colon patch in an experimental rat model for the surgical treatment of total colonic aganglionosis (TCA). Animals were randomly assigned to Group 1 (no patch, No.=6), Group 2 (right colon patch, No.=8), Group 3 (transverse colon patch, No.=7), Group 4 (left colon patch; No.=6), sham operation (SH, No.=6). and unoperated controls (UC, No.=10). Change in percent body weight at 4 weeks after operation was -30.9±3.68{\%} in Group 1, +5.1±1.67{\%} in Group 2, -3.4±3.96{\%} in Group 3, -1.8±4.17{\%} in Group 4, and +12.7±1.54{\%} in SH (Group 1 v other groups: P<.001). Restoration of initial body weight occurred in 100{\%} in Group 2 and SH (8/8 and 6/6, respectively), 50{\%} in Group 4 (3/6), 42.9{\%} in Group 3 (3/7), and 0{\%} in Group 1 (0/6). Transit time (stomach to anus) was significantly shorter in Group 1. All rats in patched groups had a prolonged transit time compared with Group 1. Manometric studies in IEP rats showed favorable anal canal pressures, which were slightly lower than SH and UC. Water and Na+ absorption were significantly greater in patched groups. Rats with a right colon patch (Group 2) showed slightly greater absorption at 4 weeks. These data suggest that an aganglionic colon patch may be an important adjunct in the surgical treatment of TCA.",
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N2 - This study evaluates ileoendorectal pull-through (IEP) with and without an aganglionic colon patch in an experimental rat model for the surgical treatment of total colonic aganglionosis (TCA). Animals were randomly assigned to Group 1 (no patch, No.=6), Group 2 (right colon patch, No.=8), Group 3 (transverse colon patch, No.=7), Group 4 (left colon patch; No.=6), sham operation (SH, No.=6). and unoperated controls (UC, No.=10). Change in percent body weight at 4 weeks after operation was -30.9±3.68% in Group 1, +5.1±1.67% in Group 2, -3.4±3.96% in Group 3, -1.8±4.17% in Group 4, and +12.7±1.54% in SH (Group 1 v other groups: P<.001). Restoration of initial body weight occurred in 100% in Group 2 and SH (8/8 and 6/6, respectively), 50% in Group 4 (3/6), 42.9% in Group 3 (3/7), and 0% in Group 1 (0/6). Transit time (stomach to anus) was significantly shorter in Group 1. All rats in patched groups had a prolonged transit time compared with Group 1. Manometric studies in IEP rats showed favorable anal canal pressures, which were slightly lower than SH and UC. Water and Na+ absorption were significantly greater in patched groups. Rats with a right colon patch (Group 2) showed slightly greater absorption at 4 weeks. These data suggest that an aganglionic colon patch may be an important adjunct in the surgical treatment of TCA.

AB - This study evaluates ileoendorectal pull-through (IEP) with and without an aganglionic colon patch in an experimental rat model for the surgical treatment of total colonic aganglionosis (TCA). Animals were randomly assigned to Group 1 (no patch, No.=6), Group 2 (right colon patch, No.=8), Group 3 (transverse colon patch, No.=7), Group 4 (left colon patch; No.=6), sham operation (SH, No.=6). and unoperated controls (UC, No.=10). Change in percent body weight at 4 weeks after operation was -30.9±3.68% in Group 1, +5.1±1.67% in Group 2, -3.4±3.96% in Group 3, -1.8±4.17% in Group 4, and +12.7±1.54% in SH (Group 1 v other groups: P<.001). Restoration of initial body weight occurred in 100% in Group 2 and SH (8/8 and 6/6, respectively), 50% in Group 4 (3/6), 42.9% in Group 3 (3/7), and 0% in Group 1 (0/6). Transit time (stomach to anus) was significantly shorter in Group 1. All rats in patched groups had a prolonged transit time compared with Group 1. Manometric studies in IEP rats showed favorable anal canal pressures, which were slightly lower than SH and UC. Water and Na+ absorption were significantly greater in patched groups. Rats with a right colon patch (Group 2) showed slightly greater absorption at 4 weeks. These data suggest that an aganglionic colon patch may be an important adjunct in the surgical treatment of TCA.

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