Surrogate markers for adverse outcomes in normotensive patients with pulmonary embolism

Jeffrey Kline, Jackeline Hernandez-Nino, Geoffrey A. Rose, H. James Norton, Carlos A. Camargo

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

BACKGROUND: Although echocardiography has proven utility in risk stratifying normotensive patients with pulmonary embolism, echocardiography is not always available. OBJECTIVE: Test if a novel panel consisting of pulse oximetry, 12-lead electrocardiography, and serum troponin T would have prognostic equivalence to echocardiography and to examine the prognostic performance of age, previous cardiopulmonary disease, D-dimer, brain natriuretic peptide, and percentage of pulmonary vascular occlusion on chest computed tomography. DESIGN: Prospective cohort study. PATIENTS AND SETTING: Normotensive (systolic blood pressure of >100 mm Hg) emergency department and hospital inpatients with diagnosed pulmonary embolism who underwent cardiologist- interpreted echocardiography and other measurements within 15 hrs of anticoagulation. MEASUREMENTS AND MAIN RESULTS: End points were in-hospital circulatory shock or intubation, or death, recurrent pulmonary embolism, or severe cardiopulmonary disability (defined as echocardiographic evidence of severe right ventricular dysfunction with New York Heart Association class III dyspnea or 6-min walk test of

Original languageEnglish (US)
Pages (from-to)2773-2780
Number of pages8
JournalCritical Care Medicine
Volume34
Issue number11
DOIs
StatePublished - Nov 2006
Externally publishedYes

Fingerprint

Pulmonary Embolism
Echocardiography
Biomarkers
Blood Pressure
Right Ventricular Dysfunction
Troponin T
Oximetry
Brain Natriuretic Peptide
Intubation
Dyspnea
Blood Vessels
Hospital Emergency Service
Inpatients
Shock
Electrocardiography
Cohort Studies
Thorax
Tomography
Prospective Studies
Lung

Keywords

  • Brain natriuretic peptide
  • D-dimer
  • Echocardiography
  • Electrocardiography
  • Fibrinolysis
  • Prognosis
  • Thromboembolism
  • Troponin

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Surrogate markers for adverse outcomes in normotensive patients with pulmonary embolism. / Kline, Jeffrey; Hernandez-Nino, Jackeline; Rose, Geoffrey A.; Norton, H. James; Camargo, Carlos A.

In: Critical Care Medicine, Vol. 34, No. 11, 11.2006, p. 2773-2780.

Research output: Contribution to journalArticle

Kline, Jeffrey ; Hernandez-Nino, Jackeline ; Rose, Geoffrey A. ; Norton, H. James ; Camargo, Carlos A. / Surrogate markers for adverse outcomes in normotensive patients with pulmonary embolism. In: Critical Care Medicine. 2006 ; Vol. 34, No. 11. pp. 2773-2780.
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