Surveillance after initial surgery for Stage i pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group

Frederick Rescorla, Jonathan H. Ross, Deborah F. Billmire, Bryan J. Dicken, Doojduen Villaluna, Mary M. Davis, Mark Krailo, John W. Cullen, Thomas A. Olson, Rachel A. Egler, James F. Amatruda, Carlos Rodrigues-Galindo, A. Lindsey Frazier

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose The purpose of this study was to determine prognostic factors correlating with outcome in boys with Stage I malignant testicular germ cell tumors (MTGCT) initially managed with surveillance after surgical resection. Methods Between November 2003 and July 2011, 80 boys 0-15 years with Stage I MTGCT were enrolled in Children's Oncology Group Study AGCT0132. Those with residual or recurrent disease were treated with chemotherapy. Results Characteristics include: age (65, 0-5 years and 15, 11 + years), pure YST (93.9%, 0-5 years and 0%, 11 + years); and lymphovascular invasion (LVI) (50.6% present vs. 49.4% absent). At median follow-up of 4.94 years, 19 had persistent or recurrent disease, all detected by elevated AFP at a median of 87 days after study enrollment. The outcome from enrollment was 4-year EFS 74% (95% CI: 63%-83%) and 4-year OS 100%. 4-year EFS was improved with younger age (<11 years, 80% vs. 11 + years, 48%, p <0.01); pure YST vs. mixed histology (81% vs. 45%, p <0.01), and lack of LVI (84% vs. 62%, p = 0.03). Conclusions Boys with Stage I MTGCT have excellent overall survival when treated with surgery alone. Age greater than 10 years, mixed histology and presence of LVI are each associated with relapse and may allow identification of high risk boys at time of enrollment.

Original languageEnglish (US)
Pages (from-to)1000-1003
Number of pages4
JournalJournal of Pediatric Surgery
Volume50
Issue number6
DOIs
StatePublished - Jun 1 2015

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Pediatrics
Histology
Recurrence
Drug Therapy
Survival
Testicular Germ Cell Tumor

Keywords

  • malignant testes germ cell tumors

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Surveillance after initial surgery for Stage i pediatric and adolescent boys with malignant testicular germ cell tumors : Report from the Children's Oncology Group. / Rescorla, Frederick; Ross, Jonathan H.; Billmire, Deborah F.; Dicken, Bryan J.; Villaluna, Doojduen; Davis, Mary M.; Krailo, Mark; Cullen, John W.; Olson, Thomas A.; Egler, Rachel A.; Amatruda, James F.; Rodrigues-Galindo, Carlos; Frazier, A. Lindsey.

In: Journal of Pediatric Surgery, Vol. 50, No. 6, 01.06.2015, p. 1000-1003.

Research output: Contribution to journalArticle

Rescorla, F, Ross, JH, Billmire, DF, Dicken, BJ, Villaluna, D, Davis, MM, Krailo, M, Cullen, JW, Olson, TA, Egler, RA, Amatruda, JF, Rodrigues-Galindo, C & Frazier, AL 2015, 'Surveillance after initial surgery for Stage i pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group', Journal of Pediatric Surgery, vol. 50, no. 6, pp. 1000-1003. https://doi.org/10.1016/j.jpedsurg.2015.03.026
Rescorla, Frederick ; Ross, Jonathan H. ; Billmire, Deborah F. ; Dicken, Bryan J. ; Villaluna, Doojduen ; Davis, Mary M. ; Krailo, Mark ; Cullen, John W. ; Olson, Thomas A. ; Egler, Rachel A. ; Amatruda, James F. ; Rodrigues-Galindo, Carlos ; Frazier, A. Lindsey. / Surveillance after initial surgery for Stage i pediatric and adolescent boys with malignant testicular germ cell tumors : Report from the Children's Oncology Group. In: Journal of Pediatric Surgery. 2015 ; Vol. 50, No. 6. pp. 1000-1003.
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abstract = "Purpose The purpose of this study was to determine prognostic factors correlating with outcome in boys with Stage I malignant testicular germ cell tumors (MTGCT) initially managed with surveillance after surgical resection. Methods Between November 2003 and July 2011, 80 boys 0-15 years with Stage I MTGCT were enrolled in Children's Oncology Group Study AGCT0132. Those with residual or recurrent disease were treated with chemotherapy. Results Characteristics include: age (65, 0-5 years and 15, 11 + years), pure YST (93.9{\%}, 0-5 years and 0{\%}, 11 + years); and lymphovascular invasion (LVI) (50.6{\%} present vs. 49.4{\%} absent). At median follow-up of 4.94 years, 19 had persistent or recurrent disease, all detected by elevated AFP at a median of 87 days after study enrollment. The outcome from enrollment was 4-year EFS 74{\%} (95{\%} CI: 63{\%}-83{\%}) and 4-year OS 100{\%}. 4-year EFS was improved with younger age (<11 years, 80{\%} vs. 11 + years, 48{\%}, p <0.01); pure YST vs. mixed histology (81{\%} vs. 45{\%}, p <0.01), and lack of LVI (84{\%} vs. 62{\%}, p = 0.03). Conclusions Boys with Stage I MTGCT have excellent overall survival when treated with surgery alone. Age greater than 10 years, mixed histology and presence of LVI are each associated with relapse and may allow identification of high risk boys at time of enrollment.",
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T1 - Surveillance after initial surgery for Stage i pediatric and adolescent boys with malignant testicular germ cell tumors

T2 - Report from the Children's Oncology Group

AU - Rescorla, Frederick

AU - Ross, Jonathan H.

AU - Billmire, Deborah F.

AU - Dicken, Bryan J.

AU - Villaluna, Doojduen

AU - Davis, Mary M.

AU - Krailo, Mark

AU - Cullen, John W.

AU - Olson, Thomas A.

AU - Egler, Rachel A.

AU - Amatruda, James F.

AU - Rodrigues-Galindo, Carlos

AU - Frazier, A. Lindsey

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Purpose The purpose of this study was to determine prognostic factors correlating with outcome in boys with Stage I malignant testicular germ cell tumors (MTGCT) initially managed with surveillance after surgical resection. Methods Between November 2003 and July 2011, 80 boys 0-15 years with Stage I MTGCT were enrolled in Children's Oncology Group Study AGCT0132. Those with residual or recurrent disease were treated with chemotherapy. Results Characteristics include: age (65, 0-5 years and 15, 11 + years), pure YST (93.9%, 0-5 years and 0%, 11 + years); and lymphovascular invasion (LVI) (50.6% present vs. 49.4% absent). At median follow-up of 4.94 years, 19 had persistent or recurrent disease, all detected by elevated AFP at a median of 87 days after study enrollment. The outcome from enrollment was 4-year EFS 74% (95% CI: 63%-83%) and 4-year OS 100%. 4-year EFS was improved with younger age (<11 years, 80% vs. 11 + years, 48%, p <0.01); pure YST vs. mixed histology (81% vs. 45%, p <0.01), and lack of LVI (84% vs. 62%, p = 0.03). Conclusions Boys with Stage I MTGCT have excellent overall survival when treated with surgery alone. Age greater than 10 years, mixed histology and presence of LVI are each associated with relapse and may allow identification of high risk boys at time of enrollment.

AB - Purpose The purpose of this study was to determine prognostic factors correlating with outcome in boys with Stage I malignant testicular germ cell tumors (MTGCT) initially managed with surveillance after surgical resection. Methods Between November 2003 and July 2011, 80 boys 0-15 years with Stage I MTGCT were enrolled in Children's Oncology Group Study AGCT0132. Those with residual or recurrent disease were treated with chemotherapy. Results Characteristics include: age (65, 0-5 years and 15, 11 + years), pure YST (93.9%, 0-5 years and 0%, 11 + years); and lymphovascular invasion (LVI) (50.6% present vs. 49.4% absent). At median follow-up of 4.94 years, 19 had persistent or recurrent disease, all detected by elevated AFP at a median of 87 days after study enrollment. The outcome from enrollment was 4-year EFS 74% (95% CI: 63%-83%) and 4-year OS 100%. 4-year EFS was improved with younger age (<11 years, 80% vs. 11 + years, 48%, p <0.01); pure YST vs. mixed histology (81% vs. 45%, p <0.01), and lack of LVI (84% vs. 62%, p = 0.03). Conclusions Boys with Stage I MTGCT have excellent overall survival when treated with surgery alone. Age greater than 10 years, mixed histology and presence of LVI are each associated with relapse and may allow identification of high risk boys at time of enrollment.

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