Survival in patients with colorectal cancer diagnosed by screening colonoscopy

Kilian Friedrich, Ludwig Grüter, Daniel Gotthardt, Christoph Eisenbach, Wolfgang Stremmel, Sabine G. Scholl, Douglas K. Rex, Andreas Sieg

Research output: Contribution to journalArticle

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Abstract

Background In Germany, screening colonoscopy was first established in 2002 as part of the national cancer screening program. Objective To evaluate whether colorectal cancer (CRC) survival differs when CRC is diagnosed by screening colonoscopy (S-CRC) versus diagnostic colonoscopy (D-CRC). Design Long-term, retrospective, multicenter, observational study. Setting Study centers: 10 private gastroenterology practices in Germany. Patients A total of 60 patients diagnosed with CRC during screening colonoscopy and 252 patients during diagnostic colonoscopy in 2002, 2003, and 2004. Interventions Colonoscopy. Main Outcome Measurements Survival of patients up to December 2013. Results Mean (± standard deviation [SD]) follow-up time was 81.0 (± 40.1) months. Union Internationale Contre le Cancer (UICC) stages I and II were found more often in S-CRC (81.6%) compared with D-CRC (59.9%; P <.002). Kaplan-Meier analysis showed significantly reduced overall survival for patients with D-CRC (mean [± SD] 86.9 [± 3.0] months; 95% confidence interval [CI], 81.0-92.8) compared with S-CRC (mean [± SD] 107.1 [± 4.9] months; 95% CI, 97.4-116.9; P =.003). When deaths not related to CRC were excluded, survival was still shorter for D-CRC patients (mean [± SD] 89.4 [± 3.0] months; 95% CI, 83.5-95.4) compared with S-CRC (mean [± SD] 109.6 [± 4.7] months; 95% CI, 100.2-119.0; P =.004). Limitations Retrospective study design. Conclusion In this long-term, retrospective study, patients with CRC diagnosed during screening colonoscopy lived significantly longer when compared with patients with CRC diagnosed during diagnostic colonoscopy.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalGastrointestinal endoscopy
Volume82
Issue number1
DOIs
StatePublished - Jul 1 2015

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Colonoscopy
Early Detection of Cancer
Colorectal Neoplasms
Survival
Confidence Intervals
Germany
Retrospective Studies
Private Practice
Kaplan-Meier Estimate
Gastroenterology
Multicenter Studies
Observational Studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Friedrich, K., Grüter, L., Gotthardt, D., Eisenbach, C., Stremmel, W., Scholl, S. G., ... Sieg, A. (2015). Survival in patients with colorectal cancer diagnosed by screening colonoscopy. Gastrointestinal endoscopy, 82(1), 133-137. https://doi.org/10.1016/j.gie.2014.12.048

Survival in patients with colorectal cancer diagnosed by screening colonoscopy. / Friedrich, Kilian; Grüter, Ludwig; Gotthardt, Daniel; Eisenbach, Christoph; Stremmel, Wolfgang; Scholl, Sabine G.; Rex, Douglas K.; Sieg, Andreas.

In: Gastrointestinal endoscopy, Vol. 82, No. 1, 01.07.2015, p. 133-137.

Research output: Contribution to journalArticle

Friedrich, K, Grüter, L, Gotthardt, D, Eisenbach, C, Stremmel, W, Scholl, SG, Rex, DK & Sieg, A 2015, 'Survival in patients with colorectal cancer diagnosed by screening colonoscopy', Gastrointestinal endoscopy, vol. 82, no. 1, pp. 133-137. https://doi.org/10.1016/j.gie.2014.12.048
Friedrich K, Grüter L, Gotthardt D, Eisenbach C, Stremmel W, Scholl SG et al. Survival in patients with colorectal cancer diagnosed by screening colonoscopy. Gastrointestinal endoscopy. 2015 Jul 1;82(1):133-137. https://doi.org/10.1016/j.gie.2014.12.048
Friedrich, Kilian ; Grüter, Ludwig ; Gotthardt, Daniel ; Eisenbach, Christoph ; Stremmel, Wolfgang ; Scholl, Sabine G. ; Rex, Douglas K. ; Sieg, Andreas. / Survival in patients with colorectal cancer diagnosed by screening colonoscopy. In: Gastrointestinal endoscopy. 2015 ; Vol. 82, No. 1. pp. 133-137.
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abstract = "Background In Germany, screening colonoscopy was first established in 2002 as part of the national cancer screening program. Objective To evaluate whether colorectal cancer (CRC) survival differs when CRC is diagnosed by screening colonoscopy (S-CRC) versus diagnostic colonoscopy (D-CRC). Design Long-term, retrospective, multicenter, observational study. Setting Study centers: 10 private gastroenterology practices in Germany. Patients A total of 60 patients diagnosed with CRC during screening colonoscopy and 252 patients during diagnostic colonoscopy in 2002, 2003, and 2004. Interventions Colonoscopy. Main Outcome Measurements Survival of patients up to December 2013. Results Mean (± standard deviation [SD]) follow-up time was 81.0 (± 40.1) months. Union Internationale Contre le Cancer (UICC) stages I and II were found more often in S-CRC (81.6{\%}) compared with D-CRC (59.9{\%}; P <.002). Kaplan-Meier analysis showed significantly reduced overall survival for patients with D-CRC (mean [± SD] 86.9 [± 3.0] months; 95{\%} confidence interval [CI], 81.0-92.8) compared with S-CRC (mean [± SD] 107.1 [± 4.9] months; 95{\%} CI, 97.4-116.9; P =.003). When deaths not related to CRC were excluded, survival was still shorter for D-CRC patients (mean [± SD] 89.4 [± 3.0] months; 95{\%} CI, 83.5-95.4) compared with S-CRC (mean [± SD] 109.6 [± 4.7] months; 95{\%} CI, 100.2-119.0; P =.004). Limitations Retrospective study design. Conclusion In this long-term, retrospective study, patients with CRC diagnosed during screening colonoscopy lived significantly longer when compared with patients with CRC diagnosed during diagnostic colonoscopy.",
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AU - Friedrich, Kilian

AU - Grüter, Ludwig

AU - Gotthardt, Daniel

AU - Eisenbach, Christoph

AU - Stremmel, Wolfgang

AU - Scholl, Sabine G.

AU - Rex, Douglas K.

AU - Sieg, Andreas

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N2 - Background In Germany, screening colonoscopy was first established in 2002 as part of the national cancer screening program. Objective To evaluate whether colorectal cancer (CRC) survival differs when CRC is diagnosed by screening colonoscopy (S-CRC) versus diagnostic colonoscopy (D-CRC). Design Long-term, retrospective, multicenter, observational study. Setting Study centers: 10 private gastroenterology practices in Germany. Patients A total of 60 patients diagnosed with CRC during screening colonoscopy and 252 patients during diagnostic colonoscopy in 2002, 2003, and 2004. Interventions Colonoscopy. Main Outcome Measurements Survival of patients up to December 2013. Results Mean (± standard deviation [SD]) follow-up time was 81.0 (± 40.1) months. Union Internationale Contre le Cancer (UICC) stages I and II were found more often in S-CRC (81.6%) compared with D-CRC (59.9%; P <.002). Kaplan-Meier analysis showed significantly reduced overall survival for patients with D-CRC (mean [± SD] 86.9 [± 3.0] months; 95% confidence interval [CI], 81.0-92.8) compared with S-CRC (mean [± SD] 107.1 [± 4.9] months; 95% CI, 97.4-116.9; P =.003). When deaths not related to CRC were excluded, survival was still shorter for D-CRC patients (mean [± SD] 89.4 [± 3.0] months; 95% CI, 83.5-95.4) compared with S-CRC (mean [± SD] 109.6 [± 4.7] months; 95% CI, 100.2-119.0; P =.004). Limitations Retrospective study design. Conclusion In this long-term, retrospective study, patients with CRC diagnosed during screening colonoscopy lived significantly longer when compared with patients with CRC diagnosed during diagnostic colonoscopy.

AB - Background In Germany, screening colonoscopy was first established in 2002 as part of the national cancer screening program. Objective To evaluate whether colorectal cancer (CRC) survival differs when CRC is diagnosed by screening colonoscopy (S-CRC) versus diagnostic colonoscopy (D-CRC). Design Long-term, retrospective, multicenter, observational study. Setting Study centers: 10 private gastroenterology practices in Germany. Patients A total of 60 patients diagnosed with CRC during screening colonoscopy and 252 patients during diagnostic colonoscopy in 2002, 2003, and 2004. Interventions Colonoscopy. Main Outcome Measurements Survival of patients up to December 2013. Results Mean (± standard deviation [SD]) follow-up time was 81.0 (± 40.1) months. Union Internationale Contre le Cancer (UICC) stages I and II were found more often in S-CRC (81.6%) compared with D-CRC (59.9%; P <.002). Kaplan-Meier analysis showed significantly reduced overall survival for patients with D-CRC (mean [± SD] 86.9 [± 3.0] months; 95% confidence interval [CI], 81.0-92.8) compared with S-CRC (mean [± SD] 107.1 [± 4.9] months; 95% CI, 97.4-116.9; P =.003). When deaths not related to CRC were excluded, survival was still shorter for D-CRC patients (mean [± SD] 89.4 [± 3.0] months; 95% CI, 83.5-95.4) compared with S-CRC (mean [± SD] 109.6 [± 4.7] months; 95% CI, 100.2-119.0; P =.004). Limitations Retrospective study design. Conclusion In this long-term, retrospective study, patients with CRC diagnosed during screening colonoscopy lived significantly longer when compared with patients with CRC diagnosed during diagnostic colonoscopy.

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