Susceptibility loci for pigmentation and melanoma in relation to Parkinson's disease

Jing Dong, Jianjun Gao, Michael Nalls, Xiang Gao, Xuemei Huang, Jiali Han, Andrew B. Singleton, Honglei Chen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Growing evidence suggests that Parkinson's disease (PD) patients have a lower risk for most types of cancer except for melanoma, which has a modest positive association with PD. Pigmentation genes have been hypothesized to contribute to this association. We therefore examined whether genetic susceptibility loci for pigmentation or melanoma was associated with PD risk in 2 large independent datasets. In the Parkinson's Genes and Environment (PAGE) study, we examined 11 single-nucleotide polymorphisms (SNPs) identified from previous genome-wide association studies (GWAS) of pigmentation or melanoma in relation to PD among 808 PD cases and 1623 controls; furthermore, we also examined the colors of hair, eye, or skin and melanoma in relation to PD. In the International Parkinson's Disease Genomic Consortium (IPDGC), we examined a broader selection of 360 pigmentation or melanoma GWAS SNPs in relation to PD among 5,333 PD cases and 12,019 controls. All participants were non-Hispanic Whites. As expected, in the PAGE study, most SNPs were associated with 1 or more pigmentation phenotypes. However, neither these SNPs nor pigmentation phenotypes were associated with PD risk after Bonferroni correction with the exception of rs4911414 at the ASIP gene (p= .001). A total of 18 PD cases (2.2%) and 26 controls (1.6%) had a diagnosis of melanoma with an odds ratio of 1.3 (95% confidence interval: 0.7-2.4). In the IPDGC analysis, none of the 360 SNPs, including rs4911414, were associated with PD risk after adjusting for multiple comparisons. In conclusion, we did not find significant associations between GWAS SNPs of pigmentation or melanoma and the risk for PD.

Original languageEnglish (US)
JournalNeurobiology of Aging
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2014
Externally publishedYes

Fingerprint

Pigmentation
Parkinson Disease
Melanoma
Single Nucleotide Polymorphism
Genome-Wide Association Study
Genes
Hair Color
Eye Color
Skin Pigmentation
Phenotype
Genetic Loci
Genetic Predisposition to Disease
Odds Ratio
Confidence Intervals

Keywords

  • Melanoma
  • Parkinson's disease
  • Pigmentation
  • Susceptibility

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Susceptibility loci for pigmentation and melanoma in relation to Parkinson's disease. / Dong, Jing; Gao, Jianjun; Nalls, Michael; Gao, Xiang; Huang, Xuemei; Han, Jiali; Singleton, Andrew B.; Chen, Honglei.

In: Neurobiology of Aging, Vol. 35, No. 6, 01.06.2014.

Research output: Contribution to journalArticle

Dong, Jing ; Gao, Jianjun ; Nalls, Michael ; Gao, Xiang ; Huang, Xuemei ; Han, Jiali ; Singleton, Andrew B. ; Chen, Honglei. / Susceptibility loci for pigmentation and melanoma in relation to Parkinson's disease. In: Neurobiology of Aging. 2014 ; Vol. 35, No. 6.
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abstract = "Growing evidence suggests that Parkinson's disease (PD) patients have a lower risk for most types of cancer except for melanoma, which has a modest positive association with PD. Pigmentation genes have been hypothesized to contribute to this association. We therefore examined whether genetic susceptibility loci for pigmentation or melanoma was associated with PD risk in 2 large independent datasets. In the Parkinson's Genes and Environment (PAGE) study, we examined 11 single-nucleotide polymorphisms (SNPs) identified from previous genome-wide association studies (GWAS) of pigmentation or melanoma in relation to PD among 808 PD cases and 1623 controls; furthermore, we also examined the colors of hair, eye, or skin and melanoma in relation to PD. In the International Parkinson's Disease Genomic Consortium (IPDGC), we examined a broader selection of 360 pigmentation or melanoma GWAS SNPs in relation to PD among 5,333 PD cases and 12,019 controls. All participants were non-Hispanic Whites. As expected, in the PAGE study, most SNPs were associated with 1 or more pigmentation phenotypes. However, neither these SNPs nor pigmentation phenotypes were associated with PD risk after Bonferroni correction with the exception of rs4911414 at the ASIP gene (p= .001). A total of 18 PD cases (2.2{\%}) and 26 controls (1.6{\%}) had a diagnosis of melanoma with an odds ratio of 1.3 (95{\%} confidence interval: 0.7-2.4). In the IPDGC analysis, none of the 360 SNPs, including rs4911414, were associated with PD risk after adjusting for multiple comparisons. In conclusion, we did not find significant associations between GWAS SNPs of pigmentation or melanoma and the risk for PD.",
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