Susceptibility of middle adolescent females to sexually transmitted infections

Impact of hormone contraception and sexual behaviors on vaginal immunity

Melissa M. Barousse, Katherine P. Theall, Barbara Van Der Pol, J. Fortenberry, Donald P. Orr, Paul L. Fidel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Problem: The resistance and/or susceptibility to infections can be influenced by patterns of immunomodulators. Based on this and the high rate of sexually transmitted infections (STIs) in adolescents, we examined the longitudinal relationship between sexual behaviors, hormonal contraceptive use, and bacterial vaginosis (BV) with vaginal-associated immunomodulators in adolescent females. Methods of study: Over 27 months, subjects completed detailed questionnaires, and consented to vaginal swabs for STI testing, and vaginal lavages for identification of immunomodulators including T-helper, proinflammatory, and chemokines. Concentrations of immunomodulators were correlated with each parameter together with prevalence of STIs. Results: Each parameter had a limited influence on vaginal immunomodulators with no evidence of any pattern(s) associated with infection. Conversely, the local presence of proinflammatory cytokines and neutrophils in those with an STI indicated some immune responsiveness. Conclusion: Sexual behaviors, contraceptive usage, and BV do not appear as factors in susceptibility of adolescents to STIs through the influence of local immunomodulators.

Original languageEnglish
Pages (from-to)159-168
Number of pages10
JournalAmerican Journal of Reproductive Immunology
Volume58
Issue number2
DOIs
StatePublished - Aug 2007

Fingerprint

Contraception Behavior
Immunologic Factors
Sexually Transmitted Diseases
Sexual Behavior
Immunity
Hormones
Bacterial Vaginosis
Vaginal Douching
Contraceptive Agents
Infection
Chemokines
Neutrophils
Cytokines

Keywords

  • Adolescent behaviors
  • Adolescents
  • Sexually transmitted infections
  • Vaginal immunity

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynecology

Cite this

Susceptibility of middle adolescent females to sexually transmitted infections : Impact of hormone contraception and sexual behaviors on vaginal immunity. / Barousse, Melissa M.; Theall, Katherine P.; Van Der Pol, Barbara; Fortenberry, J.; Orr, Donald P.; Fidel, Paul L.

In: American Journal of Reproductive Immunology, Vol. 58, No. 2, 08.2007, p. 159-168.

Research output: Contribution to journalArticle

Barousse, Melissa M. ; Theall, Katherine P. ; Van Der Pol, Barbara ; Fortenberry, J. ; Orr, Donald P. ; Fidel, Paul L. / Susceptibility of middle adolescent females to sexually transmitted infections : Impact of hormone contraception and sexual behaviors on vaginal immunity. In: American Journal of Reproductive Immunology. 2007 ; Vol. 58, No. 2. pp. 159-168.
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