SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease

Ariana Bevilacqua, Monte Willis, Scott J. Bultman

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Our understanding of congenital heart defects has been recently advanced by whole exome sequencing projects, which have identified de novo mutations in many genes encoding epigenetic regulators. Notably, multiple subunits of switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complexes have been identified as strong candidates underlying these defects because they physically and functionally interact with cardiogenic transcription factors critical to cardiac development, such as TBX5, GATA-4, and NKX2-5. While these studies indicate a critical role of SWI/SNF complexes in cardiac development and congenital heart disease, many exciting new discoveries have identified their critical role in the adult heart in both physiological and pathological conditions involving multiple cell types in the heart, including cardiomyocytes, vascular endothelial cells, pericytes, and neural crest cells. This review summarizes the role of SWI/SNF chromatin-remodeling complexes in cardiac development, congenital heart disease, cardiac hypertrophy, and vascular endothelial cell survival. Although the clinical relevance of SWI/SNF mutations has traditionally been focused primarily on their role in tumor suppression, these recent studies illustrate their critical role in the heart whereby they regulate cell proliferation, differentiation, and apoptosis of cardiac derived cell lines.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalCardiovascular Pathology
Volume23
Issue number2
DOIs
StatePublished - Mar 1 2014
Externally publishedYes

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Chromatin Assembly and Disassembly
Sucrose
Cardiovascular Diseases
Heart Diseases
Endothelial Cells
Exome
Pericytes
Mutation
Congenital Heart Defects
Neural Crest
Cardiomegaly
Cardiac Myocytes
Epigenomics
Cell Differentiation
Cell Survival
Transcription Factors
Cell Proliferation
Apoptosis
Cell Line
Genes

Keywords

  • BAF250a
  • BRG1
  • BRM
  • Cardiovascular
  • Epigenetics
  • SWI/SNF

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease. / Bevilacqua, Ariana; Willis, Monte; Bultman, Scott J.

In: Cardiovascular Pathology, Vol. 23, No. 2, 01.03.2014, p. 85-91.

Research output: Contribution to journalReview article

Bevilacqua, Ariana ; Willis, Monte ; Bultman, Scott J. / SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease. In: Cardiovascular Pathology. 2014 ; Vol. 23, No. 2. pp. 85-91.
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