Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults with Eosinophilic Esophagitis

Ekaterina Safroneeva, Alex Straumann, Michael Coslovsky, Marcel Zwahlen, Claudia E. Kuehni, Radoslaw Panczak, Nadine A. Haas, Jeffrey A. Alexander, Evan S. Dellon, Nirmala Gonsalves, Ikuo Hirano, John Leung, Christian Bussmann, Margaret H. Collins, Robert O. Newbury, Giovanni De Petris, Thomas C. Smyrk, John T. Woosley, Pu Yan, Guang Yu YangYvonne Romero, David A. Katzka, Glenn T. Furuta, Sandeep Gupta, Seema S. Aceves, Mirna Chehade, Jonathan M. Spergel, Alain M. Schoepfer

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Background & Aims It is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission. Methods Between April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States. Patients first completed the validated symptom-based EoE activity index patient-reported outcome instrument and then underwent esophagogastroduodenoscopy with esophageal biopsy collection. Endoscopic and histologic findings were evaluated with a validated grading system and standardized instrument, respectively. Clinical remission was defined as symptom score 2 in a high-power field (corresponds to approximately

Original languageEnglish (US)
Pages (from-to)581-590e4
JournalGastroenterology
Volume150
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Eosinophilic Esophagitis
Digestive System Endoscopy
Switzerland
Observational Studies
Prospective Studies
Biopsy

Keywords

  • Disease Monitoring
  • EEsAI
  • Endoscopic Grading
  • Remission

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Safroneeva, E., Straumann, A., Coslovsky, M., Zwahlen, M., Kuehni, C. E., Panczak, R., ... Schoepfer, A. M. (2016). Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults with Eosinophilic Esophagitis. Gastroenterology, 150(3), 581-590e4. https://doi.org/10.1053/j.gastro.2015.11.004

Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults with Eosinophilic Esophagitis. / Safroneeva, Ekaterina; Straumann, Alex; Coslovsky, Michael; Zwahlen, Marcel; Kuehni, Claudia E.; Panczak, Radoslaw; Haas, Nadine A.; Alexander, Jeffrey A.; Dellon, Evan S.; Gonsalves, Nirmala; Hirano, Ikuo; Leung, John; Bussmann, Christian; Collins, Margaret H.; Newbury, Robert O.; De Petris, Giovanni; Smyrk, Thomas C.; Woosley, John T.; Yan, Pu; Yang, Guang Yu; Romero, Yvonne; Katzka, David A.; Furuta, Glenn T.; Gupta, Sandeep; Aceves, Seema S.; Chehade, Mirna; Spergel, Jonathan M.; Schoepfer, Alain M.

In: Gastroenterology, Vol. 150, No. 3, 01.03.2016, p. 581-590e4.

Research output: Contribution to journalArticle

Safroneeva, E, Straumann, A, Coslovsky, M, Zwahlen, M, Kuehni, CE, Panczak, R, Haas, NA, Alexander, JA, Dellon, ES, Gonsalves, N, Hirano, I, Leung, J, Bussmann, C, Collins, MH, Newbury, RO, De Petris, G, Smyrk, TC, Woosley, JT, Yan, P, Yang, GY, Romero, Y, Katzka, DA, Furuta, GT, Gupta, S, Aceves, SS, Chehade, M, Spergel, JM & Schoepfer, AM 2016, 'Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults with Eosinophilic Esophagitis', Gastroenterology, vol. 150, no. 3, pp. 581-590e4. https://doi.org/10.1053/j.gastro.2015.11.004
Safroneeva, Ekaterina ; Straumann, Alex ; Coslovsky, Michael ; Zwahlen, Marcel ; Kuehni, Claudia E. ; Panczak, Radoslaw ; Haas, Nadine A. ; Alexander, Jeffrey A. ; Dellon, Evan S. ; Gonsalves, Nirmala ; Hirano, Ikuo ; Leung, John ; Bussmann, Christian ; Collins, Margaret H. ; Newbury, Robert O. ; De Petris, Giovanni ; Smyrk, Thomas C. ; Woosley, John T. ; Yan, Pu ; Yang, Guang Yu ; Romero, Yvonne ; Katzka, David A. ; Furuta, Glenn T. ; Gupta, Sandeep ; Aceves, Seema S. ; Chehade, Mirna ; Spergel, Jonathan M. ; Schoepfer, Alain M. / Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults with Eosinophilic Esophagitis. In: Gastroenterology. 2016 ; Vol. 150, No. 3. pp. 581-590e4.
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