Synapse formation occurs in association with the induction of long-term potentiation in two-year-old rat hippocampus in vitro

Fen Lei F. Chang, Krystyna R. Isaacs, William T. Greenough

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Following induction of long-term potentiation in subfield CAl of the hippocampal slice from 26-month-old rats, shaft synapse numbers increased by 44% and sessile spine synapses (synapses on stubby, headless spines) by 72%, with the more common mushroom-shaped spine synapses statistically unaltered. These effects are smaller than in prior work with young adults, whereas population spike amplitude changes were comparable to young adults. Reasons for the discrepancy are unclear, but the results confirm continuing capacity for induction of LTP in aged rats and indicate that substantial synaptogenic capacity also persists, but may be impaired, at these ages.

Original languageEnglish (US)
Pages (from-to)517-522
Number of pages6
JournalNeurobiology of Aging
Volume12
Issue number5
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • Learning
  • Plasticity
  • Senescence
  • Synaptic efficacy
  • Synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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