Synchronization measures of the scalp electroencephalogram can discriminate healthy from Alzheimer's subjects

Mark A. Kramer, Fen-Lei Chang, Maurice E. Cohen, Donna Hudson, Andrew J. Szeri

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Three synchronization measures are applied to scalp electroencephalogram (EEG) data collected from 20 patients diagnosed to have either: (1) no dementia, (2) mild cognitive impairment (MCI), or (3) Alzheimer's disease (AD). We apply the three synchronization measures - the phase synchronization, and two measures of nonlinear interdependency - to the data collected from awake patients resting with eyes closed. We show that the synchronization in potential between electrodes near the left and right occipital lobes provides a statistically significant discriminant between the healthy and AD subjects, and the MCI and AD subjects. None of the three measures appears able to distinguish between the healthy and MCI subjects, although MCI subjects show synchronization values intermediate between healthy subjects (with high synchronization values) and AD subjects (with low synchronization values) on average.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalInternational Journal of Neural Systems
Volume17
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

Electroencephalography
Synchronization
Electrodes

ASJC Scopus subject areas

  • Computer Networks and Communications

Cite this

Synchronization measures of the scalp electroencephalogram can discriminate healthy from Alzheimer's subjects. / Kramer, Mark A.; Chang, Fen-Lei; Cohen, Maurice E.; Hudson, Donna; Szeri, Andrew J.

In: International Journal of Neural Systems, Vol. 17, No. 2, 04.2007, p. 61-69.

Research output: Contribution to journalArticle

Kramer, Mark A. ; Chang, Fen-Lei ; Cohen, Maurice E. ; Hudson, Donna ; Szeri, Andrew J. / Synchronization measures of the scalp electroencephalogram can discriminate healthy from Alzheimer's subjects. In: International Journal of Neural Systems. 2007 ; Vol. 17, No. 2. pp. 61-69.
@article{c9e2e660214e45268d8324aa1dc04358,
title = "Synchronization measures of the scalp electroencephalogram can discriminate healthy from Alzheimer's subjects",
abstract = "Three synchronization measures are applied to scalp electroencephalogram (EEG) data collected from 20 patients diagnosed to have either: (1) no dementia, (2) mild cognitive impairment (MCI), or (3) Alzheimer's disease (AD). We apply the three synchronization measures - the phase synchronization, and two measures of nonlinear interdependency - to the data collected from awake patients resting with eyes closed. We show that the synchronization in potential between electrodes near the left and right occipital lobes provides a statistically significant discriminant between the healthy and AD subjects, and the MCI and AD subjects. None of the three measures appears able to distinguish between the healthy and MCI subjects, although MCI subjects show synchronization values intermediate between healthy subjects (with high synchronization values) and AD subjects (with low synchronization values) on average.",
author = "Kramer, {Mark A.} and Fen-Lei Chang and Cohen, {Maurice E.} and Donna Hudson and Szeri, {Andrew J.}",
year = "2007",
month = "4",
doi = "10.1142/S0129065707000932",
language = "English",
volume = "17",
pages = "61--69",
journal = "International Journal of Neural Systems",
issn = "0129-0657",
publisher = "World Scientific Publishing Co. Pte Ltd",
number = "2",

}

TY - JOUR

T1 - Synchronization measures of the scalp electroencephalogram can discriminate healthy from Alzheimer's subjects

AU - Kramer, Mark A.

AU - Chang, Fen-Lei

AU - Cohen, Maurice E.

AU - Hudson, Donna

AU - Szeri, Andrew J.

PY - 2007/4

Y1 - 2007/4

N2 - Three synchronization measures are applied to scalp electroencephalogram (EEG) data collected from 20 patients diagnosed to have either: (1) no dementia, (2) mild cognitive impairment (MCI), or (3) Alzheimer's disease (AD). We apply the three synchronization measures - the phase synchronization, and two measures of nonlinear interdependency - to the data collected from awake patients resting with eyes closed. We show that the synchronization in potential between electrodes near the left and right occipital lobes provides a statistically significant discriminant between the healthy and AD subjects, and the MCI and AD subjects. None of the three measures appears able to distinguish between the healthy and MCI subjects, although MCI subjects show synchronization values intermediate between healthy subjects (with high synchronization values) and AD subjects (with low synchronization values) on average.

AB - Three synchronization measures are applied to scalp electroencephalogram (EEG) data collected from 20 patients diagnosed to have either: (1) no dementia, (2) mild cognitive impairment (MCI), or (3) Alzheimer's disease (AD). We apply the three synchronization measures - the phase synchronization, and two measures of nonlinear interdependency - to the data collected from awake patients resting with eyes closed. We show that the synchronization in potential between electrodes near the left and right occipital lobes provides a statistically significant discriminant between the healthy and AD subjects, and the MCI and AD subjects. None of the three measures appears able to distinguish between the healthy and MCI subjects, although MCI subjects show synchronization values intermediate between healthy subjects (with high synchronization values) and AD subjects (with low synchronization values) on average.

UR - http://www.scopus.com/inward/record.url?scp=34250162518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250162518&partnerID=8YFLogxK

U2 - 10.1142/S0129065707000932

DO - 10.1142/S0129065707000932

M3 - Article

VL - 17

SP - 61

EP - 69

JO - International Journal of Neural Systems

JF - International Journal of Neural Systems

SN - 0129-0657

IS - 2

ER -