Synchronization of adolescent blood pressure and pubertal somatic growth

Wanzhu Tu, George J. Eckert, Chandan Saha, J. Howard Pratt

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Blood pressure (BP) and growth increase at an accelerated rate during puberty. The temporal relationship of the two events has not been well characterized. Objective: The purpose of this current investigation was to examine the rate of BP change in relation to pubertal growth with the intent to shed light on new mechanisms by which BP is regulated. Methods: We examined data from a cohort of 182 normotensive children who had measurements made semiannually for up to 12 yr. From the recorded heights, we identified the subject-specific pubertal growth spurt (PGS) using a growth curve model. With the estimated PGS as an anchoring point, we obtained the rates at which BP and weight changed as continuous functions of time for the duration of pubertal growth. Examining BP on a scale relative to PGS placed BP development in the context of pubertal growth. Results: Average ages at PGS were 11.5 for girls and 13.3 for boys. Fitted spline models estimated that at the time of PGS, the mean systolic BP was 100 mm Hg for girls and 107 mm Hg for boys; the mean diastolic BP at the PGS was 59 mm Hg for girls and 61 mm Hg for boys. The most intriguing observation was that rate of change in systolic BP and weight peaked at precisely the estimated PGS. Conclusion: The time synchronization of rates of change in BP, weight, and height suggests common regulating mechanisms for somatic growth and BP or growth changes that secondarily affect BP.

Original languageEnglish
Pages (from-to)5019-5022
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number12
DOIs
StatePublished - Dec 2009

Fingerprint

Blood pressure
Synchronization
Blood Pressure
Growth
Weights and Measures
Puberty
Splines

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Synchronization of adolescent blood pressure and pubertal somatic growth. / Tu, Wanzhu; Eckert, George J.; Saha, Chandan; Pratt, J. Howard.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 12, 12.2009, p. 5019-5022.

Research output: Contribution to journalArticle

@article{903b2196a53e482c9266d0cc7de62cab,
title = "Synchronization of adolescent blood pressure and pubertal somatic growth",
abstract = "Background: Blood pressure (BP) and growth increase at an accelerated rate during puberty. The temporal relationship of the two events has not been well characterized. Objective: The purpose of this current investigation was to examine the rate of BP change in relation to pubertal growth with the intent to shed light on new mechanisms by which BP is regulated. Methods: We examined data from a cohort of 182 normotensive children who had measurements made semiannually for up to 12 yr. From the recorded heights, we identified the subject-specific pubertal growth spurt (PGS) using a growth curve model. With the estimated PGS as an anchoring point, we obtained the rates at which BP and weight changed as continuous functions of time for the duration of pubertal growth. Examining BP on a scale relative to PGS placed BP development in the context of pubertal growth. Results: Average ages at PGS were 11.5 for girls and 13.3 for boys. Fitted spline models estimated that at the time of PGS, the mean systolic BP was 100 mm Hg for girls and 107 mm Hg for boys; the mean diastolic BP at the PGS was 59 mm Hg for girls and 61 mm Hg for boys. The most intriguing observation was that rate of change in systolic BP and weight peaked at precisely the estimated PGS. Conclusion: The time synchronization of rates of change in BP, weight, and height suggests common regulating mechanisms for somatic growth and BP or growth changes that secondarily affect BP.",
author = "Wanzhu Tu and Eckert, {George J.} and Chandan Saha and Pratt, {J. Howard}",
year = "2009",
month = "12",
doi = "10.1210/jc.2009-0997",
language = "English",
volume = "94",
pages = "5019--5022",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "12",

}

TY - JOUR

T1 - Synchronization of adolescent blood pressure and pubertal somatic growth

AU - Tu, Wanzhu

AU - Eckert, George J.

AU - Saha, Chandan

AU - Pratt, J. Howard

PY - 2009/12

Y1 - 2009/12

N2 - Background: Blood pressure (BP) and growth increase at an accelerated rate during puberty. The temporal relationship of the two events has not been well characterized. Objective: The purpose of this current investigation was to examine the rate of BP change in relation to pubertal growth with the intent to shed light on new mechanisms by which BP is regulated. Methods: We examined data from a cohort of 182 normotensive children who had measurements made semiannually for up to 12 yr. From the recorded heights, we identified the subject-specific pubertal growth spurt (PGS) using a growth curve model. With the estimated PGS as an anchoring point, we obtained the rates at which BP and weight changed as continuous functions of time for the duration of pubertal growth. Examining BP on a scale relative to PGS placed BP development in the context of pubertal growth. Results: Average ages at PGS were 11.5 for girls and 13.3 for boys. Fitted spline models estimated that at the time of PGS, the mean systolic BP was 100 mm Hg for girls and 107 mm Hg for boys; the mean diastolic BP at the PGS was 59 mm Hg for girls and 61 mm Hg for boys. The most intriguing observation was that rate of change in systolic BP and weight peaked at precisely the estimated PGS. Conclusion: The time synchronization of rates of change in BP, weight, and height suggests common regulating mechanisms for somatic growth and BP or growth changes that secondarily affect BP.

AB - Background: Blood pressure (BP) and growth increase at an accelerated rate during puberty. The temporal relationship of the two events has not been well characterized. Objective: The purpose of this current investigation was to examine the rate of BP change in relation to pubertal growth with the intent to shed light on new mechanisms by which BP is regulated. Methods: We examined data from a cohort of 182 normotensive children who had measurements made semiannually for up to 12 yr. From the recorded heights, we identified the subject-specific pubertal growth spurt (PGS) using a growth curve model. With the estimated PGS as an anchoring point, we obtained the rates at which BP and weight changed as continuous functions of time for the duration of pubertal growth. Examining BP on a scale relative to PGS placed BP development in the context of pubertal growth. Results: Average ages at PGS were 11.5 for girls and 13.3 for boys. Fitted spline models estimated that at the time of PGS, the mean systolic BP was 100 mm Hg for girls and 107 mm Hg for boys; the mean diastolic BP at the PGS was 59 mm Hg for girls and 61 mm Hg for boys. The most intriguing observation was that rate of change in systolic BP and weight peaked at precisely the estimated PGS. Conclusion: The time synchronization of rates of change in BP, weight, and height suggests common regulating mechanisms for somatic growth and BP or growth changes that secondarily affect BP.

UR - http://www.scopus.com/inward/record.url?scp=73249124851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73249124851&partnerID=8YFLogxK

U2 - 10.1210/jc.2009-0997

DO - 10.1210/jc.2009-0997

M3 - Article

C2 - 19850686

AN - SCOPUS:73249124851

VL - 94

SP - 5019

EP - 5022

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 12

ER -