Synchronization of ventricular fibrillation with electrical pacing guided by optical signals

Comparison of pacing locations

Heidy Hernandez, Gyo Seung Hwang, Shien-Fong Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Wavefront synchronization is an important aspect preceding the termination of ventricular fibrillation (VF). We designed a novel approach using multi-electrode pacing that could reduce the energy consumption of successful defibrillation by more than 100-fold. We compared the efficacy of a synchronized pacing algorithm using optical recording-guided pacing at the right ventricle and the posterior left ventricle in isolated rabbit hearts. Two modes of pacing were used in the study. The electrodes were individually controlled (independent mode, ISyncP) or fired together (simultaneous mode, SSyncP) when triggered by tissue polarization at a reference site separate from the pacing sites. The hearts were stained with voltage-sensitive dye and illuminated with laser for epifluorescence imaging during pacing. The number of phase singularities of VF propagation was used to estimate the complexity of VF. A decrease in the number of PS signified a higher degree of VF organization. We found that the pacing algorithm was more effective if the pacing was applied to the posterior left ventricle than to the right ventricle. Pacing in the posterior left ventricle resulted in a 25.3% decrease in the number of PS for ISyncP and a 31% decrease for SSyncP. Pacing in the right ventricle resulted in a 29.0% decrease for ISyncP and a 2.3% increase for SSyncP. The 5mA current reflected a 27.8% decrease for ISyncP and a 32.2% decrease for SSyncP, whereas the 10mA current reflected a 27.2% decrease for ISyncP and a 5.2% increase for SSyncP. We conclude that synchronized pacing can induce VF organization, and the efficacy is higher when pacing in the left ventricle with 5 mA.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6078
DOIs
StatePublished - 2006
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics II - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Other

OtherPhotonic Therapeutics and Diagnostics II
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

Fingerprint

Synchronization
Optical recording
Electrodes
Wavefronts
Energy utilization
Dyes
Polarization
Tissue
Imaging techniques
Lasers
Electric potential

Keywords

  • Fibrillation
  • Optical mapping
  • Pacing
  • Phase singularities

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hernandez, H., Hwang, G. S., & Lin, S-F. (2006). Synchronization of ventricular fibrillation with electrical pacing guided by optical signals: Comparison of pacing locations. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6078). [60782O] https://doi.org/10.1117/12.659539

Synchronization of ventricular fibrillation with electrical pacing guided by optical signals : Comparison of pacing locations. / Hernandez, Heidy; Hwang, Gyo Seung; Lin, Shien-Fong.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6078 2006. 60782O.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hernandez, H, Hwang, GS & Lin, S-F 2006, Synchronization of ventricular fibrillation with electrical pacing guided by optical signals: Comparison of pacing locations. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6078, 60782O, Photonic Therapeutics and Diagnostics II, San Jose, CA, United States, 1/21/06. https://doi.org/10.1117/12.659539
Hernandez H, Hwang GS, Lin S-F. Synchronization of ventricular fibrillation with electrical pacing guided by optical signals: Comparison of pacing locations. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6078. 2006. 60782O https://doi.org/10.1117/12.659539
Hernandez, Heidy ; Hwang, Gyo Seung ; Lin, Shien-Fong. / Synchronization of ventricular fibrillation with electrical pacing guided by optical signals : Comparison of pacing locations. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6078 2006.
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