Synchronization of ventricular fibrillation with real-time feedback pacing: Implication to low-energy defibrillation

Hui Nam Pak, Yen Bin Liu, Hideki Hayashi, Yuji Okuyama, Peng-Sheng Chen, Shien-Fong Lin

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Wavefront synchronization is an important aspect preceding the termination of ventricular fibrillation (VF). We evaluated the defibrillation efficacy of a novel multisite pacing algorithm using optical recording-guided synchronized pacing (SyncP) in the excitable gaps. We compared the effects of SyncP with traditional overdrive pacing (ODP) at 90% of the VF cycle length (VFCL) and high-frequency pacing (HFP; 43-215 Hz) on spontaneous VF termination in isolated rabbit hearts. For SyncP, the pacing current was triggered by the activation of a reference site and was delivered when the optical potential of the pacing site was in an excitable gap. We measured VFCL and the spatial dispersion of VFCL (SDCL) from five points (3 points in the paced area and 2 points in the nonpaced area) and the distribution of phase singularities during the prepacing, pacing, and postpacing periods. The results showed that 1) the VF termination rate of SyncP (16.0%, n = 106) was higher than that of ODP (2.1%, n = 48, P <0.01) or HFP (1.6%, n = 129, P <0.0001); 2) energy consumption for SyncP (7.6 ± 9.3 mJ) was significantly lower than that of ODP (14.0 ± 14.8 mJ, P <0.0001); and 3) SyncP, but not ODP or HFP, decreased SDCL in the paced area during the pacing (P <0.01) and postpacing (P <0.05) periods compared with the prepacing period. We conclude that SyncP is effective in inducing wavefront synchronization and is more effective at facilitating spontaneous VF termination than non-SyncP.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume285
Issue number6 54-6
StatePublished - Dec 2003
Externally publishedYes

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Ventricular Fibrillation
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Keywords

  • Arrhythmia
  • Defibrillation
  • Optical mapping

ASJC Scopus subject areas

  • Physiology

Cite this

Synchronization of ventricular fibrillation with real-time feedback pacing : Implication to low-energy defibrillation. / Pak, Hui Nam; Liu, Yen Bin; Hayashi, Hideki; Okuyama, Yuji; Chen, Peng-Sheng; Lin, Shien-Fong.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 285, No. 6 54-6, 12.2003.

Research output: Contribution to journalArticle

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abstract = "Wavefront synchronization is an important aspect preceding the termination of ventricular fibrillation (VF). We evaluated the defibrillation efficacy of a novel multisite pacing algorithm using optical recording-guided synchronized pacing (SyncP) in the excitable gaps. We compared the effects of SyncP with traditional overdrive pacing (ODP) at 90{\%} of the VF cycle length (VFCL) and high-frequency pacing (HFP; 43-215 Hz) on spontaneous VF termination in isolated rabbit hearts. For SyncP, the pacing current was triggered by the activation of a reference site and was delivered when the optical potential of the pacing site was in an excitable gap. We measured VFCL and the spatial dispersion of VFCL (SDCL) from five points (3 points in the paced area and 2 points in the nonpaced area) and the distribution of phase singularities during the prepacing, pacing, and postpacing periods. The results showed that 1) the VF termination rate of SyncP (16.0{\%}, n = 106) was higher than that of ODP (2.1{\%}, n = 48, P <0.01) or HFP (1.6{\%}, n = 129, P <0.0001); 2) energy consumption for SyncP (7.6 ± 9.3 mJ) was significantly lower than that of ODP (14.0 ± 14.8 mJ, P <0.0001); and 3) SyncP, but not ODP or HFP, decreased SDCL in the paced area during the pacing (P <0.01) and postpacing (P <0.05) periods compared with the prepacing period. We conclude that SyncP is effective in inducing wavefront synchronization and is more effective at facilitating spontaneous VF termination than non-SyncP.",
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T2 - Implication to low-energy defibrillation

AU - Pak, Hui Nam

AU - Liu, Yen Bin

AU - Hayashi, Hideki

AU - Okuyama, Yuji

AU - Chen, Peng-Sheng

AU - Lin, Shien-Fong

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N2 - Wavefront synchronization is an important aspect preceding the termination of ventricular fibrillation (VF). We evaluated the defibrillation efficacy of a novel multisite pacing algorithm using optical recording-guided synchronized pacing (SyncP) in the excitable gaps. We compared the effects of SyncP with traditional overdrive pacing (ODP) at 90% of the VF cycle length (VFCL) and high-frequency pacing (HFP; 43-215 Hz) on spontaneous VF termination in isolated rabbit hearts. For SyncP, the pacing current was triggered by the activation of a reference site and was delivered when the optical potential of the pacing site was in an excitable gap. We measured VFCL and the spatial dispersion of VFCL (SDCL) from five points (3 points in the paced area and 2 points in the nonpaced area) and the distribution of phase singularities during the prepacing, pacing, and postpacing periods. The results showed that 1) the VF termination rate of SyncP (16.0%, n = 106) was higher than that of ODP (2.1%, n = 48, P <0.01) or HFP (1.6%, n = 129, P <0.0001); 2) energy consumption for SyncP (7.6 ± 9.3 mJ) was significantly lower than that of ODP (14.0 ± 14.8 mJ, P <0.0001); and 3) SyncP, but not ODP or HFP, decreased SDCL in the paced area during the pacing (P <0.01) and postpacing (P <0.05) periods compared with the prepacing period. We conclude that SyncP is effective in inducing wavefront synchronization and is more effective at facilitating spontaneous VF termination than non-SyncP.

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