Synergistic nephrotoxicity of amphotericin B and cortisone acetate in mice

A. L. Kisch, R. P. Maydew, Andrew Evan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Striking mortality in mice receiving amphotericin B and cortisone acetate concomitantly prompted studies to characterize the toxic interaction of these two drugs further. Adult female CD-1 mice received daily injections of cortisone acetate (0-50 mg/kg subcutaneously) and/or amphotericin B (0-12.5 mg/kg intraperitoneally) in a checkerboard combination dosage pattern for 30 days. Dosages of amphotericin B and cortisone acetate that produced little or no mortality individually produced significant (P

Original languageEnglish (US)
Pages (from-to)789-794
Number of pages6
JournalJournal of Infectious Diseases
Volume137
Issue number6
StatePublished - 1978
Externally publishedYes

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Amphotericin B
Mortality
Poisons
Drug Interactions
Injections
cortisone acetate

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Synergistic nephrotoxicity of amphotericin B and cortisone acetate in mice. / Kisch, A. L.; Maydew, R. P.; Evan, Andrew.

In: Journal of Infectious Diseases, Vol. 137, No. 6, 1978, p. 789-794.

Research output: Contribution to journalArticle

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