Synergistic tumor promoter effects of estrone and progesterone in methylnitrosourea-induced rat mammary cancer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Tumor promoter effects of steroid hormones were tested in ovariectomized rats treated with the tumor initiator, methylnitrosourea. Continuous treatment with low doses of estrone induced tumor in 55% of experimental animals while intact control animals had a 96-100% incidence. Although progesterone alone produced no tumors in ovariectomized, methylnitrosourea-treated animals, estrone and progesterone acted synergistically, inducing tumorigenesis in 88% of treated rats. These results point to an important interaction between estrogens and progestins in promoting mammary tumorigenesis.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalCancer Letters
Volume179
Issue number2
DOIs
StatePublished - May 28 2002

Fingerprint

Methylnitrosourea
Estrone
Carcinogens
Progesterone
Breast Neoplasms
Carcinogenesis
Progestins
Neoplasms
Estrogens
Breast
Steroids
Hormones
Incidence

Keywords

  • Estrogen
  • Mammary tumorigenesis
  • Methylnitrosourea
  • Progesterone
  • Rat

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Synergistic tumor promoter effects of estrone and progesterone in methylnitrosourea-induced rat mammary cancer. / Bigsby, Robert M.

In: Cancer Letters, Vol. 179, No. 2, 28.05.2002, p. 113-119.

Research output: Contribution to journalArticle

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