Synovial fluid concentrations of diclofenac in patients with rheumatoid arthritis or osteoarthritis

Merrill Benson, M. Aldo-Benson, K. D. Brandt

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

These preliminary data conform earlier results in the international literature that diclofenac penetrates rapidly into synovial fluid, peaks in concentration at three to four hours after a single oral dose, and is present in substantially higher concentrations in synovial fluid than in plasma at four hours after dosing and beyond. In addition, it appears that diclofenac does not accumulate in the plasma over a one-week period of a twice-daily dose of 75 mg. Higher synovial fluid levels are sustained, however, for periods up to 12 hours after single or multiple dosing. These results suggest that, despite a short half-life in plasma, diclofenac persists at the site of inflammation, and this may help explain this extended duration of therapeutic effect after plasma levels have decreased. Persistence of diclofenac in the synovial fluid at 12 hours may account for its effectiveness on a twice-daily dosing regimen and may justify this recommendation.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalSeminars in Arthritis and Rheumatism
Volume15
Issue number2 SUPPL. 1
StatePublished - 1985

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Diclofenac
Synovial Fluid
Osteoarthritis
Rheumatoid Arthritis
Therapeutic Uses
Half-Life
Inflammation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Synovial fluid concentrations of diclofenac in patients with rheumatoid arthritis or osteoarthritis. / Benson, Merrill; Aldo-Benson, M.; Brandt, K. D.

In: Seminars in Arthritis and Rheumatism, Vol. 15, No. 2 SUPPL. 1, 1985, p. 65-67.

Research output: Contribution to journalArticle

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