Synovial membrane and cartilage changes in experimental osteoarthrosis

M. Lukoschek, M. B. Schaffler, David Burr, R. D. Boyd, E. L. Radin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The Hulth instability model was performed on 25 rabbit knee joints. Electron-microscopic, light-microscopic, and histomorphometric data demonstrated consistent chondrocyte alterations and cartilage destruction. The comparison between operated, sham, and control knees shows that surgical intervention without surgically induced instability is followed by changes in the synovial membrane and cartilage. The cartilage destruction is preceded by a synovial reaction, suggesting that the inflammatory response has an important role in the onset of cartilage damage in this model. The damage was more severe in the experimental knees, suggesting that mechanical instability is also a factor in cartilage destruction.

Original languageEnglish (US)
Pages (from-to)475-492
Number of pages18
JournalJournal of Orthopaedic Research
Volume6
Issue number4
StatePublished - 1988
Externally publishedYes

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Synovial Membrane
Osteoarthritis
Cartilage
Knee
Chondrocytes
Knee Joint
Electrons
Rabbits
Light

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Lukoschek, M., Schaffler, M. B., Burr, D., Boyd, R. D., & Radin, E. L. (1988). Synovial membrane and cartilage changes in experimental osteoarthrosis. Journal of Orthopaedic Research, 6(4), 475-492.

Synovial membrane and cartilage changes in experimental osteoarthrosis. / Lukoschek, M.; Schaffler, M. B.; Burr, David; Boyd, R. D.; Radin, E. L.

In: Journal of Orthopaedic Research, Vol. 6, No. 4, 1988, p. 475-492.

Research output: Contribution to journalArticle

Lukoschek, M, Schaffler, MB, Burr, D, Boyd, RD & Radin, EL 1988, 'Synovial membrane and cartilage changes in experimental osteoarthrosis', Journal of Orthopaedic Research, vol. 6, no. 4, pp. 475-492.
Lukoschek M, Schaffler MB, Burr D, Boyd RD, Radin EL. Synovial membrane and cartilage changes in experimental osteoarthrosis. Journal of Orthopaedic Research. 1988;6(4):475-492.
Lukoschek, M. ; Schaffler, M. B. ; Burr, David ; Boyd, R. D. ; Radin, E. L. / Synovial membrane and cartilage changes in experimental osteoarthrosis. In: Journal of Orthopaedic Research. 1988 ; Vol. 6, No. 4. pp. 475-492.
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