Synovial membrane and cartilage changes in experimental osteoarthrosis

M. Lukoschek, M. B. Schaffler, D. B. Burr, R. D. Boyd, E. L. Radin

Research output: Contribution to journalArticle

62 Scopus citations


The Hulth instability model was performed on 25 rabbit knee joints. Electron‐microscopic, light‐microscopic, and histomorphometric data demonstrated consistent chondrocyte alterations and cartilage destruction. The comparison between operated, sham, and control knees shows that surgical intervention without surgically induced instability is followed by changes in the synovial membrane and cartilage. The cartilage destruction is preceded by a synovial reaction, suggesting that the inflammatory response has an important role in the onset of cartilage damage in this model. The damage was more severe in the experimental knees, suggesting that mechanical instability is also a factor in cartilge destruction.

Original languageEnglish (US)
Pages (from-to)475-492
Number of pages18
JournalJournal of Orthopaedic Research
Issue number4
StatePublished - Jul 1988


  • Articular cartilage
  • Hulth model
  • Osteoarthrosis
  • Synovium

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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  • Cite this

    Lukoschek, M., Schaffler, M. B., Burr, D. B., Boyd, R. D., & Radin, E. L. (1988). Synovial membrane and cartilage changes in experimental osteoarthrosis. Journal of Orthopaedic Research, 6(4), 475-492.