Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors

Hyun Suk Lim, Jeong Ju Park, Kwangseok Ko, Mee Hyun Lee, Sung Kee Chung

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.

Original languageEnglish (US)
Pages (from-to)2499-2503
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number10
DOIs
StatePublished - May 17 2004

    Fingerprint

Keywords

  • EDG/S1P receptors
  • Relative binding affinities
  • Sphingosine-1-phosphate analogues
  • Structure-activity relationships

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this