Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors

Hyun-Suk Lim, Jeong Ju Park, Kwangseok Ko, Mee Hyun Lee, Sung Kee Chung

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.

Original languageEnglish (US)
Pages (from-to)2499-2503
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number10
DOIs
StatePublished - May 17 2004
Externally publishedYes

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Lysosphingolipid Receptors
Ligands
Biological Phenomena
Structure-Activity Relationship
sphingosine 1-phosphate

Keywords

  • EDG/S1P receptors
  • Relative binding affinities
  • Sphingosine-1-phosphate analogues
  • Structure-activity relationships

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. / Lim, Hyun-Suk; Park, Jeong Ju; Ko, Kwangseok; Lee, Mee Hyun; Chung, Sung Kee.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 10, 17.05.2004, p. 2499-2503.

Research output: Contribution to journalArticle

Lim, Hyun-Suk ; Park, Jeong Ju ; Ko, Kwangseok ; Lee, Mee Hyun ; Chung, Sung Kee. / Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 10. pp. 2499-2503.
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