Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors

Hyun Suk Lim, Yong Seok Oh, Pann Ghill Suh, Sung Kee Chung

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1, -3, and -5.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number2
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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