Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines

Tien L. Huang, Qian Zhang, Angele T. White, Sherry Queener, Marilyn S. Bartlett, James W. Smith, Isaac O. Donkor

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A series of novel piperidine-linked aromatic diimidazolines (3-7) have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii drug, Pentamidine. These compounds significantly inhibited the growth of Pneumocystis carinii in culture at 1 μg/mL.

Original languageEnglish
Pages (from-to)2087-2090
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number17
DOIs
StatePublished - Sep 3 1996

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Pentamidine
Pneumocystis carinii
Pharmaceutical Preparations
Growth
piperidine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines. / Huang, Tien L.; Zhang, Qian; White, Angele T.; Queener, Sherry; Bartlett, Marilyn S.; Smith, James W.; Donkor, Isaac O.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 17, 03.09.1996, p. 2087-2090.

Research output: Contribution to journalArticle

Huang, Tien L. ; Zhang, Qian ; White, Angele T. ; Queener, Sherry ; Bartlett, Marilyn S. ; Smith, James W. ; Donkor, Isaac O. / Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 17. pp. 2087-2090.
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