Synthesis and anti-Pneumocystis carinii activity of piperidine-linked aromatic diimidazolines

Tien L. Huang, Qian Zhang, Angele T. White, Sherry F. Queener, Marilyn S. Bartlett, James W. Smith, Isaac O. Donkor

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A series of novel piperidine-linked aromatic diimidazolines (3-7) have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii drug, Pentamidine. These compounds significantly inhibited the growth of Pneumocystis carinii in culture at 1 μg/mL.

Original languageEnglish (US)
Pages (from-to)2087-2090
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number17
DOIs
StatePublished - Sep 3 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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