Synthesis and bioassay of a protein tyrosine phosphatase inhibitor, dephostatin

Libing Yu, Andrea McGill, Johnny Ramirez, Peng George Wang, Zhong-Yin Zhang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The synthesis of natural product, dephostatin, is described. Both dephostatin and N-methyl-N-nitrosoaniline are found to inactivate the homogeneous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time dependent manner.

Original languageEnglish (US)
Pages (from-to)1003-1006
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number9
DOIs
StatePublished - May 4 1995
Externally publishedYes

Fingerprint

Protein Tyrosine Phosphatases
Bioassay
Biological Assay
Yersinia
Biological Products
dephostatin
N-methyl-N-nitrosoaniline

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and bioassay of a protein tyrosine phosphatase inhibitor, dephostatin. / Yu, Libing; McGill, Andrea; Ramirez, Johnny; Wang, Peng George; Zhang, Zhong-Yin.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 5, No. 9, 04.05.1995, p. 1003-1006.

Research output: Contribution to journalArticle

Yu, Libing ; McGill, Andrea ; Ramirez, Johnny ; Wang, Peng George ; Zhang, Zhong-Yin. / Synthesis and bioassay of a protein tyrosine phosphatase inhibitor, dephostatin. In: Bioorganic and Medicinal Chemistry Letters. 1995 ; Vol. 5, No. 9. pp. 1003-1006.
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