Synthesis and bioassay of a protein tyrosine phosphatase inhibitor, dephostatin

Libing Yu, Andrea McGill, Johnny Ramirez, Peng George Wang, Zhong Yin Zhang

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The synthesis of natural product, dephostatin, is described. Both dephostatin and N-methyl-N-nitrosoaniline are found to inactivate the homogeneous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time dependent manner.

Original languageEnglish (US)
Pages (from-to)1003-1006
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number9
DOIs
StatePublished - May 4 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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