Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33

Elizabeth E. Sugg, Jennifer E. Shook, Mariangela Serra, Murray Korc, Henry I. Yamamura, Thomas F. Burks, Victor J. Hruby

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Abstract

Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity.

Original languageEnglish (US)
Pages (from-to)1623-1629
Number of pages7
JournalLife Sciences
Volume39
Issue number18
DOIs
StatePublished - Nov 3 1986

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Sugg, E. E., Shook, J. E., Serra, M., Korc, M., Yamamura, H. I., Burks, T. F., & Hruby, V. J. (1986). Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33. Life Sciences, 39(18), 1623-1629. https://doi.org/10.1016/0024-3205(86)90158-X