Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors

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A series of salicylate-based compounds were designed and synthesized based on the simple function group replacement from our previously reported catechol-containing inhibitors of methionine aminopeptidase (MetAP). Some of these salicylate derivatives showed similar potency and metalloform selectivity, and some showed considerable antibacterial activity. These findings are consistent with our previous conclusion that Fe(II) is the likely metal used by MetAP in bacterial cells and provide new lead structures that can be further developed as novel antibacterial agents.

Original languageEnglish (US)
Pages (from-to)7151-7154
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number23
StatePublished - Dec 1 2011


  • Antibacterial
  • Drug discovery
  • Inhibition
  • Metalloenzyme
  • Salicylic acid

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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