Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors

Wen Long Wang, Sergio C. Chai, Qizhuang Ye

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A series of salicylate-based compounds were designed and synthesized based on the simple function group replacement from our previously reported catechol-containing inhibitors of methionine aminopeptidase (MetAP). Some of these salicylate derivatives showed similar potency and metalloform selectivity, and some showed considerable antibacterial activity. These findings are consistent with our previous conclusion that Fe(II) is the likely metal used by MetAP in bacterial cells and provide new lead structures that can be further developed as novel antibacterial agents.

Original languageEnglish
Pages (from-to)7151-7154
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number23
DOIs
StatePublished - Dec 1 2011

Fingerprint

Aminopeptidases
Salicylates
Methionine
Metals
Anti-Bacterial Agents
Derivatives
Lead
catechol

Keywords

  • Antibacterial
  • Drug discovery
  • Inhibition
  • Metalloenzyme
  • Salicylic acid

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors. / Wang, Wen Long; Chai, Sergio C.; Ye, Qizhuang.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 23, 01.12.2011, p. 7151-7154.

Research output: Contribution to journalArticle

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