Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors

Omar A. Ibrahimi, Li Wu, Kang Zhao, Zhong-Yin Zhang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Nonpeptidyl aryloxymethylphosphonates were prepared and evaluated as protein tyrosine phosphatase inhibitors. The results suggest that aryloxymethylphosphonates are effective nonhydrolyzable phosphotyrosine surrogates and provide further insight into the molecular mechanisms by which phosphate mimics inhibit phosphatase function. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number5
DOIs
StatePublished - Mar 6 2000
Externally publishedYes

Fingerprint

Phosphotyrosine
Protein Tyrosine Phosphatases
Phosphoric Monoester Hydrolases
Phosphates

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors. / Ibrahimi, Omar A.; Wu, Li; Zhao, Kang; Zhang, Zhong-Yin.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 5, 06.03.2000, p. 457-460.

Research output: Contribution to journalArticle

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