Synthesis and characterization of novel halloysite-incorporated adhesive resins

Sabrina Feitosa, Eliseu A. Münchow, Afnan O. Al-Zain, Krzysztof Kamocki, Jeffrey Platt, Marco C. Bottino

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective To investigate the effects of Halloysite® aluminosilicate clay nanotubes (HNTs) addition on selected physical, mechanical, and biological properties of experimental adhesive resins. Methods Experimental dentin adhesive resins were prepared by mixing Bis-GMA, TEGDMA, HEMA (50/25/25 wt.%), and photo-initiators. As-received HNTs were then incorporated into the resin mixture at distinct concentrations: 0 (HNT-free, control), 1, 2.5, 5, 7.5, 10, and 20 wt.%. The degree of conversion (DC), radiopacity (RP), Knoop hardness (KHN), flexural strength (FS), and cytotoxicity analyses were carried out for each adhesive formulation. The adhesive resin of Adper Scotchbond Multi-Purpose (SBMP) was used as the commercially available reference for both the RP and cytotoxicity tests. Data were statistically analyzed using One-Way ANOVA and Tukey's test (p ≤ 0.05). Results All adhesives exhibited similar DC (p = 0.1931). The RP of adhesives was improved with the addition of up to 5 wt.% of HNTs (p <0.001). Adhesives containing 5-10 wt.% of HNTs led to greater KHN when compared to the control (p <0.001). The FS was reduced only when 20 wt.% of HNTs was added (p ≤ 0.001). None of the prepared adhesives was cytotoxic. Conclusion The incorporation of up to 10 wt.% of HNTs into the adhesive resins did not jeopardize the tested physical and biological properties. Clinical significance When using HNTs as carriers of drugs/bioactive compounds, the amount of the former added into adhesive resin materials should not exceed 10 wt.%; otherwise, a significant reduction in physicomechanical properties may be expected.

Original languageEnglish (US)
Pages (from-to)1316-1322
Number of pages7
JournalJournal of Dentistry
Volume43
Issue number11
DOIs
StatePublished - Nov 1 2015

Fingerprint

Adhesives
Nanotubes
clay
Hardness
Bisphenol A-Glycidyl Methacrylate
Drug Carriers
aluminosilicate
Dentin
Analysis of Variance

Keywords

  • Adhesive
  • Cytotoxicity
  • Drug delivery
  • Halloysite
  • Nanotubes
  • Radiopacity

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Synthesis and characterization of novel halloysite-incorporated adhesive resins. / Feitosa, Sabrina; Münchow, Eliseu A.; Al-Zain, Afnan O.; Kamocki, Krzysztof; Platt, Jeffrey; Bottino, Marco C.

In: Journal of Dentistry, Vol. 43, No. 11, 01.11.2015, p. 1316-1322.

Research output: Contribution to journalArticle

Feitosa, Sabrina ; Münchow, Eliseu A. ; Al-Zain, Afnan O. ; Kamocki, Krzysztof ; Platt, Jeffrey ; Bottino, Marco C. / Synthesis and characterization of novel halloysite-incorporated adhesive resins. In: Journal of Dentistry. 2015 ; Vol. 43, No. 11. pp. 1316-1322.
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abstract = "Objective To investigate the effects of Halloysite{\circledR} aluminosilicate clay nanotubes (HNTs) addition on selected physical, mechanical, and biological properties of experimental adhesive resins. Methods Experimental dentin adhesive resins were prepared by mixing Bis-GMA, TEGDMA, HEMA (50/25/25 wt.{\%}), and photo-initiators. As-received HNTs were then incorporated into the resin mixture at distinct concentrations: 0 (HNT-free, control), 1, 2.5, 5, 7.5, 10, and 20 wt.{\%}. The degree of conversion (DC), radiopacity (RP), Knoop hardness (KHN), flexural strength (FS), and cytotoxicity analyses were carried out for each adhesive formulation. The adhesive resin of Adper Scotchbond Multi-Purpose (SBMP) was used as the commercially available reference for both the RP and cytotoxicity tests. Data were statistically analyzed using One-Way ANOVA and Tukey's test (p ≤ 0.05). Results All adhesives exhibited similar DC (p = 0.1931). The RP of adhesives was improved with the addition of up to 5 wt.{\%} of HNTs (p <0.001). Adhesives containing 5-10 wt.{\%} of HNTs led to greater KHN when compared to the control (p <0.001). The FS was reduced only when 20 wt.{\%} of HNTs was added (p ≤ 0.001). None of the prepared adhesives was cytotoxic. Conclusion The incorporation of up to 10 wt.{\%} of HNTs into the adhesive resins did not jeopardize the tested physical and biological properties. Clinical significance When using HNTs as carriers of drugs/bioactive compounds, the amount of the former added into adhesive resin materials should not exceed 10 wt.{\%}; otherwise, a significant reduction in physicomechanical properties may be expected.",
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AU - Feitosa, Sabrina

AU - Münchow, Eliseu A.

AU - Al-Zain, Afnan O.

AU - Kamocki, Krzysztof

AU - Platt, Jeffrey

AU - Bottino, Marco C.

PY - 2015/11/1

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N2 - Objective To investigate the effects of Halloysite® aluminosilicate clay nanotubes (HNTs) addition on selected physical, mechanical, and biological properties of experimental adhesive resins. Methods Experimental dentin adhesive resins were prepared by mixing Bis-GMA, TEGDMA, HEMA (50/25/25 wt.%), and photo-initiators. As-received HNTs were then incorporated into the resin mixture at distinct concentrations: 0 (HNT-free, control), 1, 2.5, 5, 7.5, 10, and 20 wt.%. The degree of conversion (DC), radiopacity (RP), Knoop hardness (KHN), flexural strength (FS), and cytotoxicity analyses were carried out for each adhesive formulation. The adhesive resin of Adper Scotchbond Multi-Purpose (SBMP) was used as the commercially available reference for both the RP and cytotoxicity tests. Data were statistically analyzed using One-Way ANOVA and Tukey's test (p ≤ 0.05). Results All adhesives exhibited similar DC (p = 0.1931). The RP of adhesives was improved with the addition of up to 5 wt.% of HNTs (p <0.001). Adhesives containing 5-10 wt.% of HNTs led to greater KHN when compared to the control (p <0.001). The FS was reduced only when 20 wt.% of HNTs was added (p ≤ 0.001). None of the prepared adhesives was cytotoxic. Conclusion The incorporation of up to 10 wt.% of HNTs into the adhesive resins did not jeopardize the tested physical and biological properties. Clinical significance When using HNTs as carriers of drugs/bioactive compounds, the amount of the former added into adhesive resin materials should not exceed 10 wt.%; otherwise, a significant reduction in physicomechanical properties may be expected.

AB - Objective To investigate the effects of Halloysite® aluminosilicate clay nanotubes (HNTs) addition on selected physical, mechanical, and biological properties of experimental adhesive resins. Methods Experimental dentin adhesive resins were prepared by mixing Bis-GMA, TEGDMA, HEMA (50/25/25 wt.%), and photo-initiators. As-received HNTs were then incorporated into the resin mixture at distinct concentrations: 0 (HNT-free, control), 1, 2.5, 5, 7.5, 10, and 20 wt.%. The degree of conversion (DC), radiopacity (RP), Knoop hardness (KHN), flexural strength (FS), and cytotoxicity analyses were carried out for each adhesive formulation. The adhesive resin of Adper Scotchbond Multi-Purpose (SBMP) was used as the commercially available reference for both the RP and cytotoxicity tests. Data were statistically analyzed using One-Way ANOVA and Tukey's test (p ≤ 0.05). Results All adhesives exhibited similar DC (p = 0.1931). The RP of adhesives was improved with the addition of up to 5 wt.% of HNTs (p <0.001). Adhesives containing 5-10 wt.% of HNTs led to greater KHN when compared to the control (p <0.001). The FS was reduced only when 20 wt.% of HNTs was added (p ≤ 0.001). None of the prepared adhesives was cytotoxic. Conclusion The incorporation of up to 10 wt.% of HNTs into the adhesive resins did not jeopardize the tested physical and biological properties. Clinical significance When using HNTs as carriers of drugs/bioactive compounds, the amount of the former added into adhesive resin materials should not exceed 10 wt.%; otherwise, a significant reduction in physicomechanical properties may be expected.

KW - Adhesive

KW - Cytotoxicity

KW - Drug delivery

KW - Halloysite

KW - Nanotubes

KW - Radiopacity

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