Synthesis and cytotoxic activity of selenophenfurin, a new inhibitor of IMP dehydrogenase

L. Cappellacci, P. Franchetti, G. Abu Sheikha, H. N. Jayaram, V. V. Gurudutt, T. Sint, B. P. Schneider, B. M. Goldstein, G. Perra, S. Poma, P. La Colla, M. Grifantini

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The synthesis of 5-β-D-ribofuranosylselenophene-3-carboxamide (selenophenfurin) is reported. Selenophenfurin was found active as cytotoxic agent and as inosine monophosphate dehydrogenase inhibitor.

Original languageEnglish (US)
Pages (from-to)1045-1048
Number of pages4
JournalNucleosides and Nucleotides
Volume16
Issue number7-9
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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    Cappellacci, L., Franchetti, P., Abu Sheikha, G., Jayaram, H. N., Gurudutt, V. V., Sint, T., Schneider, B. P., Goldstein, B. M., Perra, G., Poma, S., La Colla, P., & Grifantini, M. (1997). Synthesis and cytotoxic activity of selenophenfurin, a new inhibitor of IMP dehydrogenase. Nucleosides and Nucleotides, 16(7-9), 1045-1048. https://doi.org/10.1080/07328319708006129