Synthesis and evaluation of a monocationic copper(II) radiopharmaceutical derived from N-(2-pyridylmethyl)-N'-(salicylaldimino)- 1,3-propanediamine

Moleephan Sri-Aran, Carla J. Mathias, John K. Lim, Mark Green

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The monocationic 67Cu complex of N-(2-pyridylmethyl)-N'- (salicylaldimino)-1,3-propanediamine was obtained in high radiochemical purity by reaction of 67Cu2+ with the ligand in ethanol solution. Although this compound exhibited low heart uptake, the desired myocardial retention was observed over the 30 min time period studied in a rat model. Since the octanol/water partition coefficient of [67Cu]Cu(II)-[N-(2- pyridylmethyl)-N'-(salicylaldiminato)-1,3-propanediamine] is lower than a value believed to be the optimal myocardial uptake, it is likely that derivatives of this compound with a higher lipophilicity merit further investigation for use in myocardial imaging with copper radioisotopes.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalNuclear Medicine and Biology
Volume25
Issue number2
DOIs
StatePublished - Feb 1998
Externally publishedYes

Fingerprint

Radiopharmaceuticals
Copper Radioisotopes
Copper
Octanols
Ethanol
Ligands
Water
trimethylenediamine

Keywords

  • Copper-62
  • Copper-67
  • Myocardial imaging

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Synthesis and evaluation of a monocationic copper(II) radiopharmaceutical derived from N-(2-pyridylmethyl)-N'-(salicylaldimino)- 1,3-propanediamine. / Sri-Aran, Moleephan; Mathias, Carla J.; Lim, John K.; Green, Mark.

In: Nuclear Medicine and Biology, Vol. 25, No. 2, 02.1998, p. 107-110.

Research output: Contribution to journalArticle

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