Synthesis and IMP dehydrogenase (type I and type II) inhibitory activity of isosteric NAD analogs derived from thiophenfurin and furanfurin

P. Franchetti, L. Cappellacci, G. Abu Sheikha, H. N. Jayaram, B. P. Schneider, T. Sint, V. V. Gurudutt, F. R. Collart, E. Huberman, M. Grifantini

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2 Scopus citations

Abstract

Thiophene-3-carboxamide adenine dinucleotide (TFAD), and furan-3- carboxamide adenine dinucleotide (FFAD), two NAD analogs, were synthesized and evaluated as inhibitors of inosine monophosphate dehydrogenase type I and type II.

Original languageEnglish (US)
Pages (from-to)1415-1418
Number of pages4
JournalNucleosides and Nucleotides
Volume16
Issue number7-9
DOIs
StatePublished - Jan 1 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Franchetti, P., Cappellacci, L., Abu Sheikha, G., Jayaram, H. N., Schneider, B. P., Sint, T., Gurudutt, V. V., Collart, F. R., Huberman, E., & Grifantini, M. (1997). Synthesis and IMP dehydrogenase (type I and type II) inhibitory activity of isosteric NAD analogs derived from thiophenfurin and furanfurin. Nucleosides and Nucleotides, 16(7-9), 1415-1418. https://doi.org/10.1080/07328319708006195