Synthesis and IMP dehydrogenase (type I and type II) inhibitory activity of isosteric NAD analogs derived from thiophenfurin and furanfurin

P. Franchetti, L. Cappellacci, G. Abu Sheikha, H. N. Jayaram, Bryan Schneider, T. Sint, V. V. Gurudutt, F. R. Collart, E. Huberman, M. Grifantini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Thiophene-3-carboxamide adenine dinucleotide (TFAD), and furan-3- carboxamide adenine dinucleotide (FFAD), two NAD analogs, were synthesized and evaluated as inhibitors of inosine monophosphate dehydrogenase type I and type II.

Original languageEnglish
Pages (from-to)1415-1418
Number of pages4
JournalNucleosides and Nucleotides
Volume16
Issue number7-9
StatePublished - 1997

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IMP Dehydrogenase
Adenine
NAD
Thiophenes
Inosine Monophosphate
Oxidoreductases
thiophenfurin
furanfurin

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Franchetti, P., Cappellacci, L., Abu Sheikha, G., Jayaram, H. N., Schneider, B., Sint, T., ... Grifantini, M. (1997). Synthesis and IMP dehydrogenase (type I and type II) inhibitory activity of isosteric NAD analogs derived from thiophenfurin and furanfurin. Nucleosides and Nucleotides, 16(7-9), 1415-1418.

Synthesis and IMP dehydrogenase (type I and type II) inhibitory activity of isosteric NAD analogs derived from thiophenfurin and furanfurin. / Franchetti, P.; Cappellacci, L.; Abu Sheikha, G.; Jayaram, H. N.; Schneider, Bryan; Sint, T.; Gurudutt, V. V.; Collart, F. R.; Huberman, E.; Grifantini, M.

In: Nucleosides and Nucleotides, Vol. 16, No. 7-9, 1997, p. 1415-1418.

Research output: Contribution to journalArticle

Franchetti, P, Cappellacci, L, Abu Sheikha, G, Jayaram, HN, Schneider, B, Sint, T, Gurudutt, VV, Collart, FR, Huberman, E & Grifantini, M 1997, 'Synthesis and IMP dehydrogenase (type I and type II) inhibitory activity of isosteric NAD analogs derived from thiophenfurin and furanfurin', Nucleosides and Nucleotides, vol. 16, no. 7-9, pp. 1415-1418.
Franchetti, P. ; Cappellacci, L. ; Abu Sheikha, G. ; Jayaram, H. N. ; Schneider, Bryan ; Sint, T. ; Gurudutt, V. V. ; Collart, F. R. ; Huberman, E. ; Grifantini, M. / Synthesis and IMP dehydrogenase (type I and type II) inhibitory activity of isosteric NAD analogs derived from thiophenfurin and furanfurin. In: Nucleosides and Nucleotides. 1997 ; Vol. 16, No. 7-9. pp. 1415-1418.
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