Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT

Xuan Liu, Qi-Huang Zheng, Xiangshu Fei, Ji Quan Wang, David W. Ohannesian, Leonard C. Erickson, K. Lee Stone, Gary Hutchins

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Novel radiolabeled O6-benzylguanine derivatives, 6-O-[11C]-[(methoxymethyl)benzyl]guanines ([11C]p-O6-MMBG, 1a; [11C]m-O6-MMBG, 1b; ([11C]o-O6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT).

Original languageEnglish
Pages (from-to)641-644
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number4
DOIs
StatePublished - Feb 2003

Fingerprint

Positron emission tomography
Guanine
DNA Repair
Positron-Emission Tomography
Repair
Breast Neoplasms
Derivatives
Imaging techniques
DNA
Proteins
DNA alkyltransferase
O(6)-benzylguanine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT. / Liu, Xuan; Zheng, Qi-Huang; Fei, Xiangshu; Wang, Ji Quan; Ohannesian, David W.; Erickson, Leonard C.; Stone, K. Lee; Hutchins, Gary.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 4, 02.2003, p. 641-644.

Research output: Contribution to journalArticle

@article{87926f8b30074aaa91212afbbd298eaa,
title = "Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT",
abstract = "Novel radiolabeled O6-benzylguanine derivatives, 6-O-[11C]-[(methoxymethyl)benzyl]guanines ([11C]p-O6-MMBG, 1a; [11C]m-O6-MMBG, 1b; ([11C]o-O6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT).",
author = "Xuan Liu and Qi-Huang Zheng and Xiangshu Fei and Wang, {Ji Quan} and Ohannesian, {David W.} and Erickson, {Leonard C.} and Stone, {K. Lee} and Gary Hutchins",
year = "2003",
month = "2",
doi = "10.1016/S0960-894X(02)01048-X",
language = "English",
volume = "13",
pages = "641--644",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT

AU - Liu, Xuan

AU - Zheng, Qi-Huang

AU - Fei, Xiangshu

AU - Wang, Ji Quan

AU - Ohannesian, David W.

AU - Erickson, Leonard C.

AU - Stone, K. Lee

AU - Hutchins, Gary

PY - 2003/2

Y1 - 2003/2

N2 - Novel radiolabeled O6-benzylguanine derivatives, 6-O-[11C]-[(methoxymethyl)benzyl]guanines ([11C]p-O6-MMBG, 1a; [11C]m-O6-MMBG, 1b; ([11C]o-O6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT).

AB - Novel radiolabeled O6-benzylguanine derivatives, 6-O-[11C]-[(methoxymethyl)benzyl]guanines ([11C]p-O6-MMBG, 1a; [11C]m-O6-MMBG, 1b; ([11C]o-O6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT).

UR - http://www.scopus.com/inward/record.url?scp=0037293854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037293854&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(02)01048-X

DO - 10.1016/S0960-894X(02)01048-X

M3 - Article

VL - 13

SP - 641

EP - 644

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 4

ER -