Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT

Xuan Liu, Qi Huang Zheng, Xiangshu Fei, Ji Quan Wang, David W. Ohannesian, Leonard C. Erickson, K. Lee Stone, Gary D. Hutchins

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Novel radiolabeled O6-benzylguanine derivatives, 6-O-[11C]-[(methoxymethyl)benzyl]guanines ([11C]p-O6-MMBG, 1a; [11C]m-O6-MMBG, 1b; ([11C]o-O6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT).

Original languageEnglish (US)
Pages (from-to)641-644
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number4
DOIs
StatePublished - Feb 2003

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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