We have recently reported the synthesis and potent in vitro anti-pneumocystis carinii activity of a series of piperidine-linked aromatic diimidazolines (Bioorg. Med. Chem. Lett., 6: 2087-2090, 1996). As an extension of this work aimed at studying the effect of restricting the conformational flexibility of pentamidine congeners on anti-P. carinii activity, we have synthesized several congeners of pentamidine with conformationally restricted linkers separating the benzamidine or benzimidazoline groups. These linkers (X) are of different ring sizes and geometry. The synthesis and biological activities of this new series of compounds will be presented.
|Original language||English (US)|
|State||Published - Dec 1 1997|
ASJC Scopus subject areas
- Molecular Biology