Synthesis, anti-pneumocystis carinii activity, and DNA binding affinity of a new series of conformational constrained pentamidine congeners

Q. Zhang, A. T. White, M. Malbrue, T. L. Huang, Sherry Queener, I. O. Donkor

Research output: Contribution to journalArticle

Abstract

We have recently reported the synthesis and potent in vitro anti-pneumocystis carinii activity of a series of piperidine-linked aromatic diimidazolines (Bioorg. Med. Chem. Lett., 6: 2087-2090, 1996). As an extension of this work aimed at studying the effect of restricting the conformational flexibility of pentamidine congeners on anti-P. carinii activity, we have synthesized several congeners of pentamidine with conformationally restricted linkers separating the benzamidine or benzimidazoline groups. These linkers (X) are of different ring sizes and geometry. The synthesis and biological activities of this new series of compounds will be presented.

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Pentamidine
Pneumocystis carinii
piperidines
synthesis
DNA
Bioactivity
aromatic compounds
bioactive properties
Geometry
geometry
benzamidine
In Vitro Techniques
piperidine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Synthesis, anti-pneumocystis carinii activity, and DNA binding affinity of a new series of conformational constrained pentamidine congeners. / Zhang, Q.; White, A. T.; Malbrue, M.; Huang, T. L.; Queener, Sherry; Donkor, I. O.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

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AU - Queener, Sherry

AU - Donkor, I. O.

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