Synthesis, anti-pneumocystis carinii activity, and DNA binding affinity of a new series of conformational constrained pentamidine congeners

Q. Zhang, A. T. White, M. Malbrue, T. L. Huang, S. F. Queener, I. O. Donkor

Research output: Contribution to journalArticle

Abstract

We have recently reported the synthesis and potent in vitro anti-pneumocystis carinii activity of a series of piperidine-linked aromatic diimidazolines (Bioorg. Med. Chem. Lett., 6: 2087-2090, 1996). As an extension of this work aimed at studying the effect of restricting the conformational flexibility of pentamidine congeners on anti-P. carinii activity, we have synthesized several congeners of pentamidine with conformationally restricted linkers separating the benzamidine or benzimidazoline groups. These linkers (X) are of different ring sizes and geometry. The synthesis and biological activities of this new series of compounds will be presented.

Original languageEnglish (US)
Pages (from-to)A125
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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