Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues

Xiangshu Fei, Qi-Huang Zheng, Ji Quan Wang, K. Lee Stone, Tanya D. Martinez, Kathy Miller, George W. Sledge, Gary Hutchins

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Radiolabeled antimitotic agents [11C]T138067 and [ 18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1α implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [11C]T138067 in both MCF-7 transfected with IL-1α tumor and MDA-MB-435 tumor are non-specific binding.

Original languageEnglish
Pages (from-to)1247-1251
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number5
DOIs
StatePublished - Mar 8 2004

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Antimitotic Agents
Positron emission tomography
Positron-Emission Tomography
Imaging techniques
Interleukin-1
Nude Mice
Tumors
Tumor Biomarkers
Neoplasms
Animals
Animal Models
Breast Neoplasms
batabulin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues. / Fei, Xiangshu; Zheng, Qi-Huang; Wang, Ji Quan; Stone, K. Lee; Martinez, Tanya D.; Miller, Kathy; Sledge, George W.; Hutchins, Gary.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 5, 08.03.2004, p. 1247-1251.

Research output: Contribution to journalArticle

Fei, Xiangshu ; Zheng, Qi-Huang ; Wang, Ji Quan ; Stone, K. Lee ; Martinez, Tanya D. ; Miller, Kathy ; Sledge, George W. ; Hutchins, Gary. / Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 5. pp. 1247-1251.
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