Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues

Xiangshu Fei, Qi Huang Zheng, Ji Quan Wang, K. Lee Stone, Tanya D. Martinez, Kathy D. Miller, George W. Sledge, Gary D. Hutchins

Research output: Contribution to journalArticle

8 Scopus citations


Radiolabeled antimitotic agents [11C]T138067 and [ 18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1α implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [11C]T138067 in both MCF-7 transfected with IL-1α tumor and MDA-MB-435 tumor are non-specific binding.

Original languageEnglish (US)
Pages (from-to)1247-1251
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number5
StatePublished - Mar 8 2004


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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