Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands

Mingzhang Gao, Deyuan Kong, Abraham Clearfield, Qi-Huang Zheng

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid) receptor ligands to image brain diseases. The single crystal structure of the most potent compound N-acetyl-1-(4′-chlorophenyl)-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline (5a) is first reported.

Original languageEnglish
Pages (from-to)2229-2233
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number8
DOIs
StatePublished - Apr 15 2006

Fingerprint

Positron emission tomography
AMPA Receptors
Fluorine
Brain Diseases
Positron-Emission Tomography
Brain
Carbon
Crystal structure
Single crystals
Ligands
Derivatives
propionic acid
heliamine
(2-azidomethyl)phenylacetyl
2-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Keywords

  • 2-Amino-3-(3-hydroxy-5- methylisoxazol-4-yl)propionic acid receptor
  • Brain diseases
  • Carbon-11
  • Fluorine-18
  • N-Acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives
  • Positron emission tomography

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands. / Gao, Mingzhang; Kong, Deyuan; Clearfield, Abraham; Zheng, Qi-Huang.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 8, 15.04.2006, p. 2229-2233.

Research output: Contribution to journalArticle

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