Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands

Mingzhang Gao, Deyuan Kong, Abraham Clearfield, Qi Huang Zheng

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid) receptor ligands to image brain diseases. The single crystal structure of the most potent compound N-acetyl-1-(4′-chlorophenyl)-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline (5a) is first reported.

Original languageEnglish (US)
Pages (from-to)2229-2233
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number8
DOIs
StatePublished - Apr 15 2006

Keywords

  • 2-Amino-3-(3-hydroxy-5- methylisoxazol-4-yl)propionic acid receptor
  • Brain diseases
  • Carbon-11
  • Fluorine-18
  • N-Acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives
  • Positron emission tomography

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7- dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands'. Together they form a unique fingerprint.

  • Cite this