Synthesis of carbon-11-labeled 4-aryl-4H-chromens as new PET agents for imaging of apoptosis in cancer

Mingzhang Gao, Min Wang, Kathy Miller, Gary Hutchins, Qi-Huang Zheng

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Carbon-11-labeled 4-aryl-4H-chromenes, 2-amino-7-(dimethylamino)-4-(3-[11C]methoxy-5-methoxyphenyl)-4H-chromene-3-carbonitrile ([11C]6a), 2-amino-4-(3-bromo-4-[11C]methoxy-5-methoxyphenyl)-7-(dimethylamino)-4H-chromene-3-carbonitrile ([11C]6c), 2-amino-4-(3-[11C]methoxy-5-methoxyphenyl)-4,7-dihydropyrano[2,3-e]indole-3-carbonitrile ([11C]6d), 2-amino-4-(3-bromo-4-[11C]methoxy-5-methoxyphenyl)-4,7-dihydropyrano[2,3-e]indole-3-carbonitrile ([11C]6f), 2-amino-4-(3-[11C]methoxy-5-methoxyphenyl)-4,9-dihydropyrano[3,2-g]indole-3-carbonitrile ([11C]6g), 2-amino-4-(3-bromo-4-[11C]methoxy-5-methoxyphenyl)-4,9-dihydropyrano[3,2-g]indole-3-carbonitrile ([11C]6i), 2-amino-4-(3-[11C]methoxy-5-methoxyphenyl)-7-methyl-4,7-dihydropyrano[2,3-e]indole-3-carbonitrile ([11C]6j) and 2-amino-4-(3-bromo-4-[11C]methoxy-5-methoxyphenyl)-7-methyl-4,7-dihydropyrano[2,3-e]indole-3-carbonitrile ([11C]6l), were prepared by O-[11C]methylation of their corresponding precursors using [11C]CH3OTf under basic conditions and isolated by a simplified solid-phase extraction (SPE) method in 30-50% radiochemical yields based on [11C]CO2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 111-185 GBq/μmol.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalApplied Radiation and Isotopes
Volume68
Issue number1
DOIs
StatePublished - Jan 2010

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indoles
apoptosis
cancer
carbon
synthesis
bombardment
methylation
solid phases
purity
decay

Keywords

  • 4-aryl-4H-chromenes
  • Apoptosis
  • Cancer
  • Imaging
  • Positron emission tomography
  • Radiotracers

ASJC Scopus subject areas

  • Radiation

Cite this

Synthesis of carbon-11-labeled 4-aryl-4H-chromens as new PET agents for imaging of apoptosis in cancer. / Gao, Mingzhang; Wang, Min; Miller, Kathy; Hutchins, Gary; Zheng, Qi-Huang.

In: Applied Radiation and Isotopes, Vol. 68, No. 1, 01.2010, p. 110-116.

Research output: Contribution to journalArticle

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author = "Mingzhang Gao and Min Wang and Kathy Miller and Gary Hutchins and Qi-Huang Zheng",
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AU - Miller, Kathy

AU - Hutchins, Gary

AU - Zheng, Qi-Huang

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KW - 4-aryl-4H-chromenes

KW - Apoptosis

KW - Cancer

KW - Imaging

KW - Positron emission tomography

KW - Radiotracers

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