Synthesis of carbon-11-labeled piperidine ring of N-[ω-(6-methoxynaphthalen-1-yl)alkyl] derivatives as new selective PET σ1 receptor probes

Mingzhang Gao, Min Wang, Gary D. Hutchins, Qi Huang Zheng

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Carbon-11-labeled piperidine ring of N-[ω-(6-methoxynaphthalen-1-yl)alkyl] derivatives were first designed and synthesized as new selective PET σ1 receptor probes. The target tracers were prepared by O-[11C]methylation of their corresponding phenolic hydroxyl precursors using [11C]CH3OTf under basic conditions and isolated by a simplified SPE method in 40-50% radiochemical yields based on [11C]CO2 and decay corrected to EOB. The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at EOS was 111-185 GBq/μmol.

Original languageEnglish (US)
Pages (from-to)459-465
Number of pages7
JournalApplied Radiation and Isotopes
Volume68
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • Imaging
  • Piperidine ring of N-[ω-(6-methoxynaphthalen-1-yl)alkyl] derivatives
  • Positron emission tomography
  • Radiotracers
  • Sigma (σ) receptors

ASJC Scopus subject areas

  • Radiation

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