Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer

Min Wang, Gabrielle Lacy, Mingzhang Gao, Kathy D. Miller, George W. Sledge, Qi Huang Zheng

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Aromatase is a particularly good target in the treatment of estrogen receptor positive breast cancer. Novel carbon-11 labeled sulfonanilide analogues, N-[11C]methyl-N-(2-alkyloxy-4-nitrophenyl)-methanesulfonamide s ([11C]3a-f, alkyl = propyl, isopropyl, 1-ethyl-propyl, cyclopentyl, cyclohexyl, and cyclohexylethyl), were designed and synthesized as potential PET agents for imaging of aromatase in breast cancer.

Original languageEnglish (US)
Pages (from-to)332-336
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number2
DOIs
StatePublished - Jan 15 2007

Keywords

  • Aromatase
  • Breast cancer
  • Carbon-11
  • Positron emission tomography (PET)
  • Sulfonanilide analogues

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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